Successful Treatment of Refractory Generalized Granuloma Annulare with Upadacitinib
Granuloma annulare is a poorly understood dermatosis that, when generalized, can occur in up to 15 percent of patients. In these cases, treatment is frustrating and experimental. We report a case of a 60-year-old woman and a 41-year-old woman who demonstrated resolution of recalcitrant, generalized...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2024/8859178 |
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| author | Alexis Coican Abigail Meckley Nathan Sagasser Melinda Greenfield Eingun James Song Jessica El-Bahri |
| author_facet | Alexis Coican Abigail Meckley Nathan Sagasser Melinda Greenfield Eingun James Song Jessica El-Bahri |
| author_sort | Alexis Coican |
| collection | DOAJ |
| description | Granuloma annulare is a poorly understood dermatosis that, when generalized, can occur in up to 15 percent of patients. In these cases, treatment is frustrating and experimental. We report a case of a 60-year-old woman and a 41-year-old woman who demonstrated resolution of recalcitrant, generalized granuloma annulare (GA) following oral treatment with upadacitinib. After showing little to no response to other various treatments, such as steroids, antibiotic regimens, and systemic therapies, each patient was started on 15 mg of daily upadacitinib. At 2 months, one patient had complete clearance of all lesions while the other patient experienced noticeable improvement. Within 4 months, the other patient reached total resolution of her lesions. These cases provide evidence of a therapeutic option that may shorten disease duration and provide relief from cutaneous disease. |
| format | Article |
| id | doaj-art-c8acd40310ff4c7e8b3ac1c3bca79fe1 |
| institution | OA Journals |
| issn | 2090-6471 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-c8acd40310ff4c7e8b3ac1c3bca79fe12025-08-20T02:19:41ZengWileyCase Reports in Dermatological Medicine2090-64712024-01-01202410.1155/2024/8859178Successful Treatment of Refractory Generalized Granuloma Annulare with UpadacitinibAlexis Coican0Abigail Meckley1Nathan Sagasser2Melinda Greenfield3Eingun James Song4Jessica El-Bahri5Department of Graduate Medical EducationDepartment of Graduate Medical EducationUniversity of South FloridaAdvanced Dermatology and Cosmetic SurgeryFrontier DermatologyDepartment of Graduate Medical EducationGranuloma annulare is a poorly understood dermatosis that, when generalized, can occur in up to 15 percent of patients. In these cases, treatment is frustrating and experimental. We report a case of a 60-year-old woman and a 41-year-old woman who demonstrated resolution of recalcitrant, generalized granuloma annulare (GA) following oral treatment with upadacitinib. After showing little to no response to other various treatments, such as steroids, antibiotic regimens, and systemic therapies, each patient was started on 15 mg of daily upadacitinib. At 2 months, one patient had complete clearance of all lesions while the other patient experienced noticeable improvement. Within 4 months, the other patient reached total resolution of her lesions. These cases provide evidence of a therapeutic option that may shorten disease duration and provide relief from cutaneous disease.http://dx.doi.org/10.1155/2024/8859178 |
| spellingShingle | Alexis Coican Abigail Meckley Nathan Sagasser Melinda Greenfield Eingun James Song Jessica El-Bahri Successful Treatment of Refractory Generalized Granuloma Annulare with Upadacitinib Case Reports in Dermatological Medicine |
| title | Successful Treatment of Refractory Generalized Granuloma Annulare with Upadacitinib |
| title_full | Successful Treatment of Refractory Generalized Granuloma Annulare with Upadacitinib |
| title_fullStr | Successful Treatment of Refractory Generalized Granuloma Annulare with Upadacitinib |
| title_full_unstemmed | Successful Treatment of Refractory Generalized Granuloma Annulare with Upadacitinib |
| title_short | Successful Treatment of Refractory Generalized Granuloma Annulare with Upadacitinib |
| title_sort | successful treatment of refractory generalized granuloma annulare with upadacitinib |
| url | http://dx.doi.org/10.1155/2024/8859178 |
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