Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent Studies
Clonal hematopoiesis of indeterminate potential (CHIP) is a condition characterized by accumulation of one or several somatic mutations in hematopoietic stem cells in the bone marrow. Recent studies have provided new data on the prevalence of CHIP mutations, which are relatively common in both cance...
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| Format: | Article |
| Language: | English |
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THE HEALTHBOOK COMPANY LTD.
2021-10-01
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| Series: | healthbook TIMES. Oncology Hematology |
| Online Access: | https://doi.org/10.36000/hbT.OH.2021.09.042 |
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| author | Adrian Schmidt |
| author_facet | Adrian Schmidt |
| author_sort | Adrian Schmidt |
| collection | DOAJ |
| description | Clonal hematopoiesis of indeterminate potential (CHIP) is a condition characterized by accumulation of one or several somatic mutations in hematopoietic stem cells in the bone marrow. Recent studies have provided new data on the prevalence of CHIP mutations, which are relatively common in both cancer patients and the general population, and especially in older adults. Adverse clinical outcomes pertaining to hematopoietic clonality have also been observed in asymptomatic, apparently healthy individuals, such as cytopenia, cardiovascular complications, and/or overt blood cancers. However, there are currently no consensus guidelines on screening or monitoring for CHIP. New insights from recent studies will help to identify subgroups of patients who will benefit from routine CHIP screening, preventative measures, and early tailored intervention. |
| format | Article |
| id | doaj-art-c8ac28c17dfd4ca0ae360fbc1492b999 |
| institution | DOAJ |
| issn | 2673-2092 2673-2106 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | THE HEALTHBOOK COMPANY LTD. |
| record_format | Article |
| series | healthbook TIMES. Oncology Hematology |
| spelling | doaj-art-c8ac28c17dfd4ca0ae360fbc1492b9992025-08-20T03:14:40ZengTHE HEALTHBOOK COMPANY LTD.healthbook TIMES. Oncology Hematology2673-20922673-21062021-10-019310.36000/hbT.OH.2021.09.042Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent StudiesAdrian SchmidtClonal hematopoiesis of indeterminate potential (CHIP) is a condition characterized by accumulation of one or several somatic mutations in hematopoietic stem cells in the bone marrow. Recent studies have provided new data on the prevalence of CHIP mutations, which are relatively common in both cancer patients and the general population, and especially in older adults. Adverse clinical outcomes pertaining to hematopoietic clonality have also been observed in asymptomatic, apparently healthy individuals, such as cytopenia, cardiovascular complications, and/or overt blood cancers. However, there are currently no consensus guidelines on screening or monitoring for CHIP. New insights from recent studies will help to identify subgroups of patients who will benefit from routine CHIP screening, preventative measures, and early tailored intervention.https://doi.org/10.36000/hbT.OH.2021.09.042 |
| spellingShingle | Adrian Schmidt Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent Studies healthbook TIMES. Oncology Hematology |
| title | Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent Studies |
| title_full | Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent Studies |
| title_fullStr | Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent Studies |
| title_full_unstemmed | Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent Studies |
| title_short | Clonal Hematopoiesis of Indeterminate Potential: New Insights from Recent Studies |
| title_sort | clonal hematopoiesis of indeterminate potential new insights from recent studies |
| url | https://doi.org/10.36000/hbT.OH.2021.09.042 |
| work_keys_str_mv | AT adrianschmidt clonalhematopoiesisofindeterminatepotentialnewinsightsfromrecentstudies |