DBS in the restoration of motor functional recovery following spinal cord injury
The landscape of therapeutic deep brain stimulation (DBS) for locomotor function recovery is rapidly evolving. This review provides an overview of electrical neuromodulation effects on spinal cord injury (SCI), focusing on DBS for motor functional recovery in human and animal models. We highlight re...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1442281/full |
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| author | Wen-yuan Li Wen-yuan Li Wen-rui Qu Yi Li Yi Li Shu-ying Wang Shu-ying Wang Dong-ming Liu Ling-xiao Deng Ying Wang Ying Wang |
| author_facet | Wen-yuan Li Wen-yuan Li Wen-rui Qu Yi Li Yi Li Shu-ying Wang Shu-ying Wang Dong-ming Liu Ling-xiao Deng Ying Wang Ying Wang |
| author_sort | Wen-yuan Li |
| collection | DOAJ |
| description | The landscape of therapeutic deep brain stimulation (DBS) for locomotor function recovery is rapidly evolving. This review provides an overview of electrical neuromodulation effects on spinal cord injury (SCI), focusing on DBS for motor functional recovery in human and animal models. We highlight research providing insight into underlying cellular and molecular mechanisms. A literature review via Web of Science and PubMed databases from 1990 to May 29, 2024, reveals a growing body of evidence for therapeutic DBS in SCI recovery. Advances in techniques like optogenetics and whole-brain tractogram have helped elucidate DBS mechanisms. Neuronal targets sites for SCI functional recovery include the mesencephalic locomotor region (MLR), cuneiform nucleus (CNF), and nucleus raphe magnus (NRG), with pedunculopontine nucleus (PPN), periaqueductal gray (PAG), and nucleus ventroposterolateral thalami (VPL) for post-injury functional recovery treatment. Radiologically guided DBS optimization and combination therapy with classical rehabilitation have become an effective therapeutic method, though ongoing interventional trials are needed to enhance understanding and validate DBS efficacy in SCI. On the pre-clinical front, standardization of pre-clinical approaches are essential to enhance the quality of evidence on DBS safety and efficacy. Mapping brain targets and optimizing DBS protocols, aided by combined DBS and medical imaging, are critical endeavors. Overall, DBS holds promise for neurological and functional recovery after SCI, akin to other electrical stimulation approaches. |
| format | Article |
| id | doaj-art-c8aad77c5558468eb5fe85ddb1eeba29 |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-c8aad77c5558468eb5fe85ddb1eeba292025-08-20T02:30:28ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-12-011510.3389/fneur.2024.14422811442281DBS in the restoration of motor functional recovery following spinal cord injuryWen-yuan Li0Wen-yuan Li1Wen-rui Qu2Yi Li3Yi Li4Shu-ying Wang5Shu-ying Wang6Dong-ming Liu7Ling-xiao Deng8Ying Wang9Ying Wang10Mudanjiang North Medicine Resource Development and Application Collaborative Innovation Center, Mudanjiang, ChinaInstitute of Neural Tissue Engineering, Mudanjiang University of Medicine, Mudanjiang, ChinaDepartment of Hand Surgery, The Second Hospital of Jilin University, Changchun, ChinaMudanjiang North Medicine Resource Development and Application Collaborative Innovation Center, Mudanjiang, ChinaInstitute of Neural Tissue Engineering, Mudanjiang University of Medicine, Mudanjiang, ChinaMudanjiang North Medicine Resource Development and Application Collaborative Innovation Center, Mudanjiang, ChinaInstitute of Neural Tissue Engineering, Mudanjiang University of Medicine, Mudanjiang, ChinaDepartment of Neurology, Mudanjiang First People’s Hospital, Mudanjiang, ChinaSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, United StatesMudanjiang North Medicine Resource Development and Application Collaborative Innovation Center, Mudanjiang, ChinaInstitute of Neural Tissue Engineering, Mudanjiang University of Medicine, Mudanjiang, ChinaThe landscape of therapeutic deep brain stimulation (DBS) for locomotor function recovery is rapidly evolving. This review provides an overview of electrical neuromodulation effects on spinal cord injury (SCI), focusing on DBS for motor functional recovery in human and animal models. We highlight research providing insight into underlying cellular and molecular mechanisms. A literature review via Web of Science and PubMed databases from 1990 to May 29, 2024, reveals a growing body of evidence for therapeutic DBS in SCI recovery. Advances in techniques like optogenetics and whole-brain tractogram have helped elucidate DBS mechanisms. Neuronal targets sites for SCI functional recovery include the mesencephalic locomotor region (MLR), cuneiform nucleus (CNF), and nucleus raphe magnus (NRG), with pedunculopontine nucleus (PPN), periaqueductal gray (PAG), and nucleus ventroposterolateral thalami (VPL) for post-injury functional recovery treatment. Radiologically guided DBS optimization and combination therapy with classical rehabilitation have become an effective therapeutic method, though ongoing interventional trials are needed to enhance understanding and validate DBS efficacy in SCI. On the pre-clinical front, standardization of pre-clinical approaches are essential to enhance the quality of evidence on DBS safety and efficacy. Mapping brain targets and optimizing DBS protocols, aided by combined DBS and medical imaging, are critical endeavors. Overall, DBS holds promise for neurological and functional recovery after SCI, akin to other electrical stimulation approaches.https://www.frontiersin.org/articles/10.3389/fneur.2024.1442281/fulldeep brain stimulationneural circuitsneuromodulationneuroplasticityspinal cord injurymotor function |
| spellingShingle | Wen-yuan Li Wen-yuan Li Wen-rui Qu Yi Li Yi Li Shu-ying Wang Shu-ying Wang Dong-ming Liu Ling-xiao Deng Ying Wang Ying Wang DBS in the restoration of motor functional recovery following spinal cord injury Frontiers in Neurology deep brain stimulation neural circuits neuromodulation neuroplasticity spinal cord injury motor function |
| title | DBS in the restoration of motor functional recovery following spinal cord injury |
| title_full | DBS in the restoration of motor functional recovery following spinal cord injury |
| title_fullStr | DBS in the restoration of motor functional recovery following spinal cord injury |
| title_full_unstemmed | DBS in the restoration of motor functional recovery following spinal cord injury |
| title_short | DBS in the restoration of motor functional recovery following spinal cord injury |
| title_sort | dbs in the restoration of motor functional recovery following spinal cord injury |
| topic | deep brain stimulation neural circuits neuromodulation neuroplasticity spinal cord injury motor function |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1442281/full |
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