Facile Synthesis of a Cholesterol–Doxorubicin Conjugate Using Cholesteryl-4-nitrophenolate as an Activated Ester and Biological Property Analysis

Facile Synthesis of a Cholesterol–Doxorubicin Conjugate Using Cholesteryl-4-nitrophenolate as an Activated Ester and Biological Property Analysis

Developing new biomolecule–drug conjugates as prodrugs is a promising area for natural products and pharmaceutical chemistry. Herein, a cholesterol–doxorubicin (Chol-DOX) conjugate was synthesized using cholesteryl-4-nitrophenolate as a facile, stable, and controllable activated ester. This approach...

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Bibliographic Details
Main Authors: Pedro Freitas, Dina Maciel, Jolanta Jaśkowska, Kamila Zeńczak-Tomera, Yanbiao Zhou, Guoyin Yin, Ruilong Sheng
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Organics
Subjects:
cholesterol
doxorubicin
conjugate
4-nitrophenolate
theoretical calculation
Online Access:https://www.mdpi.com/2673-401X/6/1/6
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