Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research
ObjectivesThis study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells.Materials and MethodsElectronic searches were performed in July 2023. In vivo and in vitro studies evaluating the effects of differe...
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| Format: | Article |
| Language: | English |
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Korean Academy of Conservative Dentistry
2023-11-01
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| Series: | Restorative Dentistry & Endodontics |
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| Online Access: | http://www.rde.ac/upload/pdf/rde-48-e39.pdf |
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| author | Letícia Aparecida Silva Batista Alexandre Henrique dos Reis-Prado Hebertt Gonzaga dos Santos Chaves Lara Cancella de Arantes Luís Fernando Santos Alves Morgan Carolina Bosso André Thaís Yumi Suzuki Francine Benetti |
| author_facet | Letícia Aparecida Silva Batista Alexandre Henrique dos Reis-Prado Hebertt Gonzaga dos Santos Chaves Lara Cancella de Arantes Luís Fernando Santos Alves Morgan Carolina Bosso André Thaís Yumi Suzuki Francine Benetti |
| author_sort | Letícia Aparecida Silva Batista |
| collection | DOAJ |
| description | ObjectivesThis study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells.Materials and MethodsElectronic searches were performed in July 2023. In vivo and in vitro studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed.ResultsOut of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%–38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass or MI Paste Plus (GC America), or following KF-desensitizing or Otosporin treatment (n = 3). However, orally administered drugs did not reduce pulp inflammation (n = 4). Cytotoxicity (n = 17) was primarily assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on human dental pulp cells and mouse dental papilla Cell-23 cells. Certain substances, including sodium ascorbate, butein, manganese chloride, and peroxidase, were found to reduce cytotoxicity, particularly when applied prior to bleaching. The risk of bias was high in animal studies and low in laboratory studies.ConclusionsFew in vivo studies have evaluated agents to reduce the damage caused by bleaching gel to pulp tissue. Within the limitations of these studies, it was found that topical agents were effective in reducing pulp inflammation in animals and cytotoxicity. Further analyses with human pulp are required to substantiate these findings.Trial RegistrationPROSPERO Identifier: CRD42022337192 |
| format | Article |
| id | doaj-art-c8a5305ab25e411a91585bdba6daa7ba |
| institution | Kabale University |
| issn | 2234-7658 2234-7666 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Korean Academy of Conservative Dentistry |
| record_format | Article |
| series | Restorative Dentistry & Endodontics |
| spelling | doaj-art-c8a5305ab25e411a91585bdba6daa7ba2025-08-20T03:31:10ZengKorean Academy of Conservative DentistryRestorative Dentistry & Endodontics2234-76582234-76662023-11-01484e3910.5395/rde.2023.48.e391082Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic researchLetícia Aparecida Silva BatistaAlexandre Henrique dos Reis-PradoHebertt Gonzaga dos Santos ChavesLara Cancella de ArantesLuís Fernando Santos Alves MorganCarolina Bosso AndréThaís Yumi SuzukiFrancine BenettiObjectivesThis study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells.Materials and MethodsElectronic searches were performed in July 2023. In vivo and in vitro studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed.ResultsOut of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%–38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass or MI Paste Plus (GC America), or following KF-desensitizing or Otosporin treatment (n = 3). However, orally administered drugs did not reduce pulp inflammation (n = 4). Cytotoxicity (n = 17) was primarily assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on human dental pulp cells and mouse dental papilla Cell-23 cells. Certain substances, including sodium ascorbate, butein, manganese chloride, and peroxidase, were found to reduce cytotoxicity, particularly when applied prior to bleaching. The risk of bias was high in animal studies and low in laboratory studies.ConclusionsFew in vivo studies have evaluated agents to reduce the damage caused by bleaching gel to pulp tissue. Within the limitations of these studies, it was found that topical agents were effective in reducing pulp inflammation in animals and cytotoxicity. Further analyses with human pulp are required to substantiate these findings.Trial RegistrationPROSPERO Identifier: CRD42022337192http://www.rde.ac/upload/pdf/rde-48-e39.pdfcell survivaldental pulphydrogen peroxideinflammationtooth bleachingsystematic review |
| spellingShingle | Letícia Aparecida Silva Batista Alexandre Henrique dos Reis-Prado Hebertt Gonzaga dos Santos Chaves Lara Cancella de Arantes Luís Fernando Santos Alves Morgan Carolina Bosso André Thaís Yumi Suzuki Francine Benetti Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research Restorative Dentistry & Endodontics cell survival dental pulp hydrogen peroxide inflammation tooth bleaching systematic review |
| title | Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research |
| title_full | Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research |
| title_fullStr | Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research |
| title_full_unstemmed | Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research |
| title_short | Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research |
| title_sort | can different agents reduce the damage caused by bleaching gel to pulp tissue a systematic review of basic research |
| topic | cell survival dental pulp hydrogen peroxide inflammation tooth bleaching systematic review |
| url | http://www.rde.ac/upload/pdf/rde-48-e39.pdf |
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