Research Progress on Hepatitis E Virus Culture
Hepatitis E virus (HEV) is a zoonotic pathogen and the main cause of acute viral hepatitis in China, resulting in a significant burden on public health. Developing a highly efficient in vitro culture system for HEV is crucial for understanding the determinants of HEV infection in humans and other an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/14/5/456 |
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| _version_ | 1849711016275869696 |
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| author | Jie Zhang Ziteng Liang Fan Liu Youchun Wang Weijin Huang Jianhui Nie |
| author_facet | Jie Zhang Ziteng Liang Fan Liu Youchun Wang Weijin Huang Jianhui Nie |
| author_sort | Jie Zhang |
| collection | DOAJ |
| description | Hepatitis E virus (HEV) is a zoonotic pathogen and the main cause of acute viral hepatitis in China, resulting in a significant burden on public health. Developing a highly efficient in vitro culture system for HEV is crucial for understanding the determinants of HEV infection in humans and other animals, the pathogenic mechanisms, as well as the screening and evaluation of antiviral drugs. In this paper, the research progress on HEV in vitro culture systems is reviewed to provide a convenient reference for further research on HEV, aiding comprehensive efforts toward the widespread prevention and control of related diseases. |
| format | Article |
| id | doaj-art-c8a51ec4646a47ee8159fd761a4ca529 |
| institution | DOAJ |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-c8a51ec4646a47ee8159fd761a4ca5292025-08-20T03:14:43ZengMDPI AGPathogens2076-08172025-05-0114545610.3390/pathogens14050456Research Progress on Hepatitis E Virus CultureJie Zhang0Ziteng Liang1Fan Liu2Youchun Wang3Weijin Huang4Jianhui Nie5Division of HIV/AIDS and Sexually-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, ChinaDivision of HIV/AIDS and Sexually-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, ChinaDivision of HIV/AIDS and Sexually-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, ChinaInstitute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming 650118, ChinaDivision of HIV/AIDS and Sexually-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, ChinaDivision of HIV/AIDS and Sexually-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, ChinaHepatitis E virus (HEV) is a zoonotic pathogen and the main cause of acute viral hepatitis in China, resulting in a significant burden on public health. Developing a highly efficient in vitro culture system for HEV is crucial for understanding the determinants of HEV infection in humans and other animals, the pathogenic mechanisms, as well as the screening and evaluation of antiviral drugs. In this paper, the research progress on HEV in vitro culture systems is reviewed to provide a convenient reference for further research on HEV, aiding comprehensive efforts toward the widespread prevention and control of related diseases.https://www.mdpi.com/2076-0817/14/5/456Hepatitis E viruscell cultureinfectious clonesorganoids |
| spellingShingle | Jie Zhang Ziteng Liang Fan Liu Youchun Wang Weijin Huang Jianhui Nie Research Progress on Hepatitis E Virus Culture Pathogens Hepatitis E virus cell culture infectious clones organoids |
| title | Research Progress on Hepatitis E Virus Culture |
| title_full | Research Progress on Hepatitis E Virus Culture |
| title_fullStr | Research Progress on Hepatitis E Virus Culture |
| title_full_unstemmed | Research Progress on Hepatitis E Virus Culture |
| title_short | Research Progress on Hepatitis E Virus Culture |
| title_sort | research progress on hepatitis e virus culture |
| topic | Hepatitis E virus cell culture infectious clones organoids |
| url | https://www.mdpi.com/2076-0817/14/5/456 |
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