A novel gene signature for forecasting time to next relapse in multiple sclerosis using peripheral blood mononuclear cells

A novel gene signature for forecasting time to next relapse in multiple sclerosis using peripheral blood mononuclear cells

Abstract Aim The purpose of this research study was to develop and validate a gene signature based on peripheral blood mononuclear cells (PBMCs) for predicting the time to the next relapse in multiple sclerosis (MS). Methods The GSE15245 dataset (N = 94) was divided into a training set (N = 65) and...

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Bibliographic Details
Main Authors: Huimin Zhang, Jiahui Yang, Xiaobo Zhang, Chaoyi Wu, Zhen Zhao, Ming Yang, Zhaoping Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Neurology
Subjects:
Cox regression
Gene signature
Multiple sclerosis
Peripheral blood mononuclear cells
Relapse prediction
Online Access:https://doi.org/10.1186/s12883-025-04231-3
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