Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study
Objective: To determine whether a panel of immune markers adds significant information to known correlates of risk of dementia and cognitive impairment. Background: The impact of immune mechanisms on dementia risk is incompletely characterized. Design/methods: A subsample of the Northern Manhattan S...
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Elsevier
2025-02-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354624002151 |
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| author | Mohammad Abdurrehman Sheikh Michelle P. Moon Clinton B. Wright Jose Gutierrez Minghua Liu Tatjana Rundek Ken Cheung Mady Hornig Mitchell S.V. Elkind |
| author_facet | Mohammad Abdurrehman Sheikh Michelle P. Moon Clinton B. Wright Jose Gutierrez Minghua Liu Tatjana Rundek Ken Cheung Mady Hornig Mitchell S.V. Elkind |
| author_sort | Mohammad Abdurrehman Sheikh |
| collection | DOAJ |
| description | Objective: To determine whether a panel of immune markers adds significant information to known correlates of risk of dementia and cognitive impairment. Background: The impact of immune mechanisms on dementia risk is incompletely characterized. Design/methods: A subsample of the Northern Manhattan Study, a prospective cohort study in the racially/ethnically diverse population of New York City, underwent comprehensive neuropsychological testing up to three times, at approximately 5-year intervals. Cognitive outcomes were adjudicated as no cognitive impairment, mild cognitive impairment (MCI), or dementia. Immune markers were assessed using a multiplex immunoassay on plasma samples collected at the time of the first neuropsychological test. Least absolute shrinkage and selection operator (LASSO) techniques were employed to yield a panel of immune markers linearly related to the outcome of dementia/MCI vs. no cognitive impairment. Nested logistic regression models were run to determine the independent association of the immune marker panel with dementia/MCI after adjusting for other predictors of risk. Results: Among 1179 participants (mean age 70.0 ± 8.9 years, 60% women, 68% Hispanic), immune markers improved model fit above demographic and vascular risk factors (p-value for likelihood ratio test <0.0001) as correlates of MCI/dementia. Individual immune markers found to be associated with dementia/MCI were C-X-C Motif Chemokine Ligand 9 (CXCL9) and C-C Motif Chemokine Ligand 2 (CCL2). The effect of the immune markers was comparable to traditional risk factors, with CCL2 (per SD) having almost the same effect as 1 year of aging and CXCL9 (per SD) showing approximately twice this magnitude. Conclusion: Immune markers are associated with cognitive decline and dementia outcomes in a multi-ethnic cohort. More work is needed to further characterize these associations and determine therapeutic strategies. (Funded by the National Institute of Health/National Institute of Neurological Disorders and Stroke; grant number R01 29993 (Sacco/Elkind)). |
| format | Article |
| id | doaj-art-c895b3cb57dd4586a6547ea0374bbdc9 |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-c895b3cb57dd4586a6547ea0374bbdc92025-01-26T05:05:04ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-02-0143100937Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan StudyMohammad Abdurrehman Sheikh0Michelle P. Moon1Clinton B. Wright2Jose Gutierrez3Minghua Liu4Tatjana Rundek5Ken Cheung6Mady Hornig7Mitchell S.V. Elkind8Department of Neurology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, USA; Corresponding author.Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USANational Institute of Neurological Disorders and Stroke, USADepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USADepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USADepartments of Neurology, Epidemiology, and Human Genetics, University of Miami, Miami, FL, USADepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USADepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USAObjective: To determine whether a panel of immune markers adds significant information to known correlates of risk of dementia and cognitive impairment. Background: The impact of immune mechanisms on dementia risk is incompletely characterized. Design/methods: A subsample of the Northern Manhattan Study, a prospective cohort study in the racially/ethnically diverse population of New York City, underwent comprehensive neuropsychological testing up to three times, at approximately 5-year intervals. Cognitive outcomes were adjudicated as no cognitive impairment, mild cognitive impairment (MCI), or dementia. Immune markers were assessed using a multiplex immunoassay on plasma samples collected at the time of the first neuropsychological test. Least absolute shrinkage and selection operator (LASSO) techniques were employed to yield a panel of immune markers linearly related to the outcome of dementia/MCI vs. no cognitive impairment. Nested logistic regression models were run to determine the independent association of the immune marker panel with dementia/MCI after adjusting for other predictors of risk. Results: Among 1179 participants (mean age 70.0 ± 8.9 years, 60% women, 68% Hispanic), immune markers improved model fit above demographic and vascular risk factors (p-value for likelihood ratio test <0.0001) as correlates of MCI/dementia. Individual immune markers found to be associated with dementia/MCI were C-X-C Motif Chemokine Ligand 9 (CXCL9) and C-C Motif Chemokine Ligand 2 (CCL2). The effect of the immune markers was comparable to traditional risk factors, with CCL2 (per SD) having almost the same effect as 1 year of aging and CXCL9 (per SD) showing approximately twice this magnitude. Conclusion: Immune markers are associated with cognitive decline and dementia outcomes in a multi-ethnic cohort. More work is needed to further characterize these associations and determine therapeutic strategies. (Funded by the National Institute of Health/National Institute of Neurological Disorders and Stroke; grant number R01 29993 (Sacco/Elkind)).http://www.sciencedirect.com/science/article/pii/S2666354624002151DementiaEpidemiologyInflammationMild cognitive impairment |
| spellingShingle | Mohammad Abdurrehman Sheikh Michelle P. Moon Clinton B. Wright Jose Gutierrez Minghua Liu Tatjana Rundek Ken Cheung Mady Hornig Mitchell S.V. Elkind Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study Brain, Behavior, & Immunity - Health Dementia Epidemiology Inflammation Mild cognitive impairment |
| title | Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study |
| title_full | Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study |
| title_fullStr | Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study |
| title_full_unstemmed | Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study |
| title_short | Association of a multiplex immune marker panel with incident cognitive impairment and dementia: The Northern Manhattan Study |
| title_sort | association of a multiplex immune marker panel with incident cognitive impairment and dementia the northern manhattan study |
| topic | Dementia Epidemiology Inflammation Mild cognitive impairment |
| url | http://www.sciencedirect.com/science/article/pii/S2666354624002151 |
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