Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population
The aims of this study are to establish reference values for TSH in Lebanese schoolchildren; to look at the relationship between TSH and age, gender, BMI, socioeconomic status (SES), and thyroid antibodies (TAb); and to investigate the prevalence of abnormal TAb in this population. 974 Lebanese scho...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/6372964 |
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| author | Marie-Hélène Gannagé-Yared Nicole Balech Vanessa Farah Marianne Antar Rindala Saliba Elise Chahine |
| author_facet | Marie-Hélène Gannagé-Yared Nicole Balech Vanessa Farah Marianne Antar Rindala Saliba Elise Chahine |
| author_sort | Marie-Hélène Gannagé-Yared |
| collection | DOAJ |
| description | The aims of this study are to establish reference values for TSH in Lebanese schoolchildren; to look at the relationship between TSH and age, gender, BMI, socioeconomic status (SES), and thyroid antibodies (TAb); and to investigate the prevalence of abnormal TAb in this population. 974 Lebanese schoolchildren aged 8–18 years were recruited from 10 schools of different SES. Third-generation TSH, TPO-Ab, and Tg-Ab measurements were performed using the IMMULITE chemiluminescent immunoassay. The mean TSH is
2.06±1.05 μUI/ml. TSH values are inversely correlated with age p<0.0001, are higher in boys than in girls (resp.,
2.14±1.10 and
1.98±0.99 μUI/ml,
p=0.017), and are positively correlated with BMI p<0.0001. They are also significantly higher in subjects from low-SES schools p=0.03 and in girls with positive TAb p=0.026. In boys, TSH is independently associated with age, BMI, and schools’ SES (p=0.01,
p=0.03, and
p=0.026, resp.) while in girls, the association is only significant for age and TAb (p=0.0001 and
p=0.015, resp.). The prevalence of TAb is 4.3% (3% for TPO-Ab and 2.1% for Tg-Ab). Our results showed higher TSH values in the pediatric Lebanese population compared to western populations. TSH varies according to age, gender, BMI, and SES and is associated in girls with TAb. |
| format | Article |
| id | doaj-art-c88d6da7226a4d2ebc0ccda10c4a1027 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c88d6da7226a4d2ebc0ccda10c4a10272025-08-20T02:19:45ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/63729646372964Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese PopulationMarie-Hélène Gannagé-Yared0Nicole Balech1Vanessa Farah2Marianne Antar3Rindala Saliba4Elise Chahine5Department of Endocrinology, Faculty of Medicine, Saint Joseph University, Beirut, LebanonDepartment of Endocrinology, Faculty of Medicine, Saint Joseph University, Beirut, LebanonHormonology Laboratory, Hôtel-Dieu de France Hospital, Beirut, LebanonHormonology Laboratory, Hôtel-Dieu de France Hospital, Beirut, LebanonHormonology Laboratory, Hôtel-Dieu de France Hospital, Beirut, LebanonDepartment of Endocrinology, Faculty of Medicine, Saint Joseph University, Beirut, LebanonThe aims of this study are to establish reference values for TSH in Lebanese schoolchildren; to look at the relationship between TSH and age, gender, BMI, socioeconomic status (SES), and thyroid antibodies (TAb); and to investigate the prevalence of abnormal TAb in this population. 974 Lebanese schoolchildren aged 8–18 years were recruited from 10 schools of different SES. Third-generation TSH, TPO-Ab, and Tg-Ab measurements were performed using the IMMULITE chemiluminescent immunoassay. The mean TSH is 2.06±1.05 μUI/ml. TSH values are inversely correlated with age p<0.0001, are higher in boys than in girls (resp., 2.14±1.10 and 1.98±0.99 μUI/ml, p=0.017), and are positively correlated with BMI p<0.0001. They are also significantly higher in subjects from low-SES schools p=0.03 and in girls with positive TAb p=0.026. In boys, TSH is independently associated with age, BMI, and schools’ SES (p=0.01, p=0.03, and p=0.026, resp.) while in girls, the association is only significant for age and TAb (p=0.0001 and p=0.015, resp.). The prevalence of TAb is 4.3% (3% for TPO-Ab and 2.1% for Tg-Ab). Our results showed higher TSH values in the pediatric Lebanese population compared to western populations. TSH varies according to age, gender, BMI, and SES and is associated in girls with TAb.http://dx.doi.org/10.1155/2017/6372964 |
| spellingShingle | Marie-Hélène Gannagé-Yared Nicole Balech Vanessa Farah Marianne Antar Rindala Saliba Elise Chahine Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population International Journal of Endocrinology |
| title | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
| title_full | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
| title_fullStr | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
| title_full_unstemmed | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
| title_short | Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population |
| title_sort | pediatric tsh reference intervals and prevalence of high thyroid antibodies in the lebanese population |
| url | http://dx.doi.org/10.1155/2017/6372964 |
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