Regulation of renal ischemia-reperfusion injury and tubular epithelial cell ferroptosis by pparγ m6a methylation: mechanisms and therapeutic implications

Regulation of renal ischemia-reperfusion injury and tubular epithelial cell ferroptosis by pparγ m6a methylation: mechanisms and therapeutic implications

Abstract This study aimed to elucidate the role and underlying mechanisms of Peroxisome proliferator-activated receptor gamma (PPARγ) and its m6A methylation in renal ischemia-reperfusion (I/R) injury and ferroptosis of tubular epithelial cells (TECs). High-throughput transcriptome sequencing was pe...

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Bibliographic Details
Main Authors: Wei Liu, Ziqing Xiong, Tianmei Fu, Juan Yang, Juan Zou, Yize Wu, Linju Kuang, Qian Wang, Song Li, Aiping Le
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Biology Direct
Subjects:
Renal ischemia-reperfusion injury
Tubular epithelial cells
m6a methylation
Ferroptosis
PPARγ
METTL14
Online Access:https://doi.org/10.1186/s13062-024-00515-9
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