Monitoring the response to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML)
Abstract The aim of oral tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) is to get ideal hematological, cytogenetic, molecular responses at the critical time-points. The depth of the response obtained with TKI and time to achieve this response are important for the predi...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-08-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1688 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850283425849671680 |
|---|---|
| author | Ibrahim C. Haznedaroglu |
| author_facet | Ibrahim C. Haznedaroglu |
| author_sort | Ibrahim C. Haznedaroglu |
| collection | DOAJ |
| description | Abstract
The aim of oral tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) is to get ideal hematological, cytogenetic, molecular responses at the critical time-points. The depth of the response obtained with TKI and time to achieve this response are important for the prediction of prognosis in the patient with CML. The high efficacy of the TKI treatment of CML has prompted the need for accurate methods to monitor response at levels below the landmark of CCyR. Quantification of BCR-ABL transcripts has proven to be the most sensitive method available and has shown prognostic impact with regard to progression-free survival. European LeukemiaNet (ELN) molecular program harmonized the reporting of results according to the IS (Internat?onal harmonization of Scale) in Europe. The aim of this review is to outline monitoring the response to optimal TKI treatment based on the ELN CML 2013 recommendations from the clinical point of view as a physician. Careful cytogenetic and molecular monitoring could help selecting the most convenient TKI drug and to optimize TKI treatment. Excessive monitoring may have an economical cost but failure to optimize TKI treatment may result in CML disease acceleration and death. |
| format | Article |
| id | doaj-art-c884357cfbdb45218ef8111dd0af38ef |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-c884357cfbdb45218ef8111dd0af38ef2025-08-20T01:47:47ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011Monitoring the response to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML)Ibrahim C. Haznedaroglu0Hacettepe University Medical School, Department of Hematology, Ankara-TurkeyAbstract The aim of oral tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) is to get ideal hematological, cytogenetic, molecular responses at the critical time-points. The depth of the response obtained with TKI and time to achieve this response are important for the prediction of prognosis in the patient with CML. The high efficacy of the TKI treatment of CML has prompted the need for accurate methods to monitor response at levels below the landmark of CCyR. Quantification of BCR-ABL transcripts has proven to be the most sensitive method available and has shown prognostic impact with regard to progression-free survival. European LeukemiaNet (ELN) molecular program harmonized the reporting of results according to the IS (Internat?onal harmonization of Scale) in Europe. The aim of this review is to outline monitoring the response to optimal TKI treatment based on the ELN CML 2013 recommendations from the clinical point of view as a physician. Careful cytogenetic and molecular monitoring could help selecting the most convenient TKI drug and to optimize TKI treatment. Excessive monitoring may have an economical cost but failure to optimize TKI treatment may result in CML disease acceleration and death.https://mjhid.org/index.php/mjhid/article/view/1688Tyrosine kinase inhibitor (TKI)Chronic myeloid leukemia (CML)Molecular monitoringCytogenetics |
| spellingShingle | Ibrahim C. Haznedaroglu Monitoring the response to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) Mediterranean Journal of Hematology and Infectious Diseases Tyrosine kinase inhibitor (TKI) Chronic myeloid leukemia (CML) Molecular monitoring Cytogenetics |
| title | Monitoring the response to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) |
| title_full | Monitoring the response to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) |
| title_fullStr | Monitoring the response to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) |
| title_full_unstemmed | Monitoring the response to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) |
| title_short | Monitoring the response to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) |
| title_sort | monitoring the response to tyrosine kinase inhibitor tki treatment in chronic myeloid leukemia cml |
| topic | Tyrosine kinase inhibitor (TKI) Chronic myeloid leukemia (CML) Molecular monitoring Cytogenetics |
| url | https://mjhid.org/index.php/mjhid/article/view/1688 |
| work_keys_str_mv | AT ibrahimchaznedaroglu monitoringtheresponsetotyrosinekinaseinhibitortkitreatmentinchronicmyeloidleukemiacml |