Pituitary disorders in pregnancy
The management of pituitary disorders in pregnancy presents a unique challenge for maternal medicine specialists and endocrinologists. Advances in assisted reproductive technologies (ART) mean that women with hypopituitarism are increasingly able to conceive. The pituitary undergoes significant phys...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Clinical Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1470211825002064 |
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| author | Darran Mc Donald Maria Tomkins Michael W. O’Reilly Mark Sherlock |
| author_facet | Darran Mc Donald Maria Tomkins Michael W. O’Reilly Mark Sherlock |
| author_sort | Darran Mc Donald |
| collection | DOAJ |
| description | The management of pituitary disorders in pregnancy presents a unique challenge for maternal medicine specialists and endocrinologists. Advances in assisted reproductive technologies (ART) mean that women with hypopituitarism are increasingly able to conceive. The pituitary undergoes significant physiological changes during pregnancy. Pituitary hormone replacement regimens must therefore be adjusted throughout pregnancy in an attempt to mimic these changes. Close clinical and biochemical follow-up and collaboration across specialties is essential to ensure optimal maternal and fetal outcomes. Although many women with hypopituitarism will have a normal pregnancy, rates of miscarriage, labour induction and caesarean sections are higher than the general population. Most women with hypopituitarism are diagnosed prior to pregnancy; however, some pituitary disorders including lymphocytic hypophysitis, Sheehan’s syndrome and pituitary apoplexy have a predilection to arise during pregnancy or the postpartum period. Prompt recognition of these disorders is essential to prevent potentially fatal complications and optimise maternal and fetal wellbeing. |
| format | Article |
| id | doaj-art-c874ac56715b42f9bcfdd81f22a6d761 |
| institution | Kabale University |
| issn | 1470-2118 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Medicine |
| spelling | doaj-art-c874ac56715b42f9bcfdd81f22a6d7612025-08-23T04:47:46ZengElsevierClinical Medicine1470-21182025-09-0125510048810.1016/j.clinme.2025.100488Pituitary disorders in pregnancyDarran Mc Donald0Maria Tomkins1Michael W. O’Reilly2Mark Sherlock3Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Academic Department of Endocrinology, Beaumont Hospital, RCSI Smurfit Building, Dublin, IrelandDepartment of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Academic Department of Endocrinology, Beaumont Hospital, RCSI Smurfit Building, Dublin, IrelandDepartment of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Academic Department of Endocrinology, Beaumont Hospital, RCSI Smurfit Building, Dublin, IrelandDepartment of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Academic Department of Endocrinology, Beaumont Hospital, RCSI Smurfit Building, Dublin, Ireland; Corresponding author.The management of pituitary disorders in pregnancy presents a unique challenge for maternal medicine specialists and endocrinologists. Advances in assisted reproductive technologies (ART) mean that women with hypopituitarism are increasingly able to conceive. The pituitary undergoes significant physiological changes during pregnancy. Pituitary hormone replacement regimens must therefore be adjusted throughout pregnancy in an attempt to mimic these changes. Close clinical and biochemical follow-up and collaboration across specialties is essential to ensure optimal maternal and fetal outcomes. Although many women with hypopituitarism will have a normal pregnancy, rates of miscarriage, labour induction and caesarean sections are higher than the general population. Most women with hypopituitarism are diagnosed prior to pregnancy; however, some pituitary disorders including lymphocytic hypophysitis, Sheehan’s syndrome and pituitary apoplexy have a predilection to arise during pregnancy or the postpartum period. Prompt recognition of these disorders is essential to prevent potentially fatal complications and optimise maternal and fetal wellbeing.http://www.sciencedirect.com/science/article/pii/S1470211825002064Maternal healthPregnancyPituitary disordersHypopituitarismFertility |
| spellingShingle | Darran Mc Donald Maria Tomkins Michael W. O’Reilly Mark Sherlock Pituitary disorders in pregnancy Clinical Medicine Maternal health Pregnancy Pituitary disorders Hypopituitarism Fertility |
| title | Pituitary disorders in pregnancy |
| title_full | Pituitary disorders in pregnancy |
| title_fullStr | Pituitary disorders in pregnancy |
| title_full_unstemmed | Pituitary disorders in pregnancy |
| title_short | Pituitary disorders in pregnancy |
| title_sort | pituitary disorders in pregnancy |
| topic | Maternal health Pregnancy Pituitary disorders Hypopituitarism Fertility |
| url | http://www.sciencedirect.com/science/article/pii/S1470211825002064 |
| work_keys_str_mv | AT darranmcdonald pituitarydisordersinpregnancy AT mariatomkins pituitarydisordersinpregnancy AT michaelworeilly pituitarydisordersinpregnancy AT marksherlock pituitarydisordersinpregnancy |