Adaptive cohort design and LAT1 expression scale: study protocol for a Phase 2a trial of QBS72S in breast cancer brain metastases

Adaptive cohort design and LAT1 expression scale: study protocol for a Phase 2a trial of QBS72S in breast cancer brain metastases

Abstract Background Breast cancer is the most common cause of cancer death among women and frequently metastasizes to the brain. Up to 30% of patients with breast-to-brain metastases will develop leptomeningeal disease (LMD), with poor survival, rapid neurologic decline, and no durable treatment opt...

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Main Authors: Rukayat Taiwo, Paul M. Harary, Thy T. H. Trinh, Monica Granucci, Sophie Bertrand, Brandon Carlson-Clarke, Sophia B. Chernikova, Kate Therkelsen, Mili Arora, Michelle E. Melisko, Michael Iv, Hannes Vogel, Summer Han, Christine Xie, Susie Brain, Vivian Lee, Krishna L. Bharani, Seema Nagpal, Melanie Hayden Gephart
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Breast cancer
Leptomeningeal disease
Chemotherapy
Expression profiling
Liquid biopsy
Online Access:https://doi.org/10.1186/s12885-025-14282-x
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