Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India
In clinical practice, every year approximately 150,000 children are referred with short stature (SS) based on a cut-off of fifth percentile. The most important endocrine and treatable cause of SS is growth hormone deficiency (GHD). The lack of reliable data on the prevalence of GHD in India limits e...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/2967578 |
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| author | Mathew John Ekaterina Koledova Kanakatte Mylariah Prasanna Kumar Harshal Chaudhari |
| author_facet | Mathew John Ekaterina Koledova Kanakatte Mylariah Prasanna Kumar Harshal Chaudhari |
| author_sort | Mathew John |
| collection | DOAJ |
| description | In clinical practice, every year approximately 150,000 children are referred with short stature (SS) based on a cut-off of fifth percentile. The most important endocrine and treatable cause of SS is growth hormone deficiency (GHD). The lack of reliable data on the prevalence of GHD in India limits estimation of the magnitude of this problem. The diagnosis and treatment of GHD are hurdled with various challenges, restricting the availability of growth hormone (GH) therapy to only a very limited segment of the children in India. This review will firstly summarize the gaps and challenges in diagnosis and treatment of GHD based on literature analysis. Subsequently, it presents suggestions from the members at advisory board meetings to overcome these challenges. The advisory board suggested that early initiation of the therapy could better the chances of achieving final adult height within the normal range for the population. Education and awareness about growth disorders among parents, regular training for physicians, and more emphasis on using the Indian growth charts for growth monitoring would help improve the diagnosis and treatment of children with GHD. Availability of an easy-to-use therapy delivery system could also be beneficial in improving adherence and achieving satisfactory outcomes. |
| format | Article |
| id | doaj-art-c86af2ab3cf04793bf6b211152a9bd6c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c86af2ab3cf04793bf6b211152a9bd6c2025-02-03T05:58:20ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/29675782967578Challenges in the Diagnosis and Management of Growth Hormone Deficiency in IndiaMathew John0Ekaterina Koledova1Kanakatte Mylariah Prasanna Kumar2Harshal Chaudhari3Providence Endocrine and Diabetes Specialty Centre, Thiruvananthapuram, Kerala, IndiaLead Endocrinology, Global Medical, Safety and CMO, Merck, Darmstadt, GermanyCentre for Diabetes and Endocrine Care, Bangalore, Karnataka, IndiaBiopharma, NDD and Endocrinology, Merck Specialties Pvt. Ltd., Mumbai, IndiaIn clinical practice, every year approximately 150,000 children are referred with short stature (SS) based on a cut-off of fifth percentile. The most important endocrine and treatable cause of SS is growth hormone deficiency (GHD). The lack of reliable data on the prevalence of GHD in India limits estimation of the magnitude of this problem. The diagnosis and treatment of GHD are hurdled with various challenges, restricting the availability of growth hormone (GH) therapy to only a very limited segment of the children in India. This review will firstly summarize the gaps and challenges in diagnosis and treatment of GHD based on literature analysis. Subsequently, it presents suggestions from the members at advisory board meetings to overcome these challenges. The advisory board suggested that early initiation of the therapy could better the chances of achieving final adult height within the normal range for the population. Education and awareness about growth disorders among parents, regular training for physicians, and more emphasis on using the Indian growth charts for growth monitoring would help improve the diagnosis and treatment of children with GHD. Availability of an easy-to-use therapy delivery system could also be beneficial in improving adherence and achieving satisfactory outcomes.http://dx.doi.org/10.1155/2016/2967578 |
| spellingShingle | Mathew John Ekaterina Koledova Kanakatte Mylariah Prasanna Kumar Harshal Chaudhari Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India International Journal of Endocrinology |
| title | Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India |
| title_full | Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India |
| title_fullStr | Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India |
| title_full_unstemmed | Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India |
| title_short | Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India |
| title_sort | challenges in the diagnosis and management of growth hormone deficiency in india |
| url | http://dx.doi.org/10.1155/2016/2967578 |
| work_keys_str_mv | AT mathewjohn challengesinthediagnosisandmanagementofgrowthhormonedeficiencyinindia AT ekaterinakoledova challengesinthediagnosisandmanagementofgrowthhormonedeficiencyinindia AT kanakattemylariahprasannakumar challengesinthediagnosisandmanagementofgrowthhormonedeficiencyinindia AT harshalchaudhari challengesinthediagnosisandmanagementofgrowthhormonedeficiencyinindia |