Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i>
Bioactive extracts from living plants (LR) and beach deposits (NR) of the submerged brackish water angiosperm <i>Ruppia maritima</i> were examined for their antioxidant activity and anticancer potential. LR extract scavenged effectively free radicals with IC<sub>50</sub> valu...
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2025-06-01
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| author | Alkistis Kevrekidou Nikolaos Goutzourelas Stavroula Savvidi Varvara Trachana Andreana N. Assimopoulou Ming Liu Paraskevi Malea Dimitrios Stagos |
| author_facet | Alkistis Kevrekidou Nikolaos Goutzourelas Stavroula Savvidi Varvara Trachana Andreana N. Assimopoulou Ming Liu Paraskevi Malea Dimitrios Stagos |
| author_sort | Alkistis Kevrekidou |
| collection | DOAJ |
| description | Bioactive extracts from living plants (LR) and beach deposits (NR) of the submerged brackish water angiosperm <i>Ruppia maritima</i> were examined for their antioxidant activity and anticancer potential. LR extract scavenged effectively free radicals with IC<sub>50</sub> values of 38.00 μg/mL (DPPH<sup>•</sup>), 12.00 μg/mL (ABTS<sup>•+</sup>), 281.00 μg/mL (OH<sup>•</sup>), and 53.00 μg/mL (O<sub>2</sub><sup>•</sup>), and exhibited reducing activity with an RP<sub>0.5AU</sub> value of 37.00 μg/mL. NR extract retained a significant part of LR extract’s antioxidant activity by scavenging free radicals with IC<sub>50</sub> values of 180.00 μg/mL (DPPH<sup>•</sup>), 60.00 μg/mL (ABTS<sup>•+</sup>), and 164.00 μg/mL (O<sub>2</sub><sup>•</sup>), and exhibited reducing activity with an RP<sub>0.5AU</sub> value of 107.00 μg/mL. Importantly, NR extract (IC<sub>50</sub> value: 60.00 μg/mL) exhibited much higher inhibitory activity than LR extract (IC<sub>50</sub> value: 1100.00 μg/mL) in XTT assay. HPLC analysis revealed that both <i>R. maritima</i> extracts contained phenolics, such as chicoric acid, quercetin-3-<i>O</i>-glucopyranoside, <i>p</i>-coumaric acid, 3,5-dimethoxy-4-hydroxicinnanic acid, <i>trans</i>-ferulic acid, and rutin hydrate, possessing antioxidant and/or anticancer activity. Thus, the present study showed for the first time that <i>R. maritima</i> extracts from either LR or NR are a promising source of bioactive compounds having beneficial properties for human health. |
| format | Article |
| id | doaj-art-c86aaeace52d4b1fa56e505560db7e77 |
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| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-c86aaeace52d4b1fa56e505560db7e772025-08-20T02:36:26ZengMDPI AGMolecules1420-30492025-06-013013280010.3390/molecules30132800Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i>Alkistis Kevrekidou0Nikolaos Goutzourelas1Stavroula Savvidi2Varvara Trachana3Andreana N. Assimopoulou4Ming Liu5Paraskevi Malea6Dimitrios Stagos7Laboratory of Organic Chemistry, School of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, Biopolis, 41500 Larissa, GreeceDepartment of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, Biopolis, 41500 Larissa, GreeceDepartment of Biology, Faculty of Medicine, University of Thessaly, Biopolis, 41500 Larissa, GreeceLaboratory of Organic Chemistry, School of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaDepartment of Botany, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, Biopolis, 41500 Larissa, GreeceBioactive extracts from living plants (LR) and beach deposits (NR) of the submerged brackish water angiosperm <i>Ruppia maritima</i> were examined for their antioxidant activity and anticancer potential. LR extract scavenged effectively free radicals with IC<sub>50</sub> values of 38.00 μg/mL (DPPH<sup>•</sup>), 12.00 μg/mL (ABTS<sup>•+</sup>), 281.00 μg/mL (OH<sup>•</sup>), and 53.00 μg/mL (O<sub>2</sub><sup>•</sup>), and exhibited reducing activity with an RP<sub>0.5AU</sub> value of 37.00 μg/mL. NR extract retained a significant part of LR extract’s antioxidant activity by scavenging free radicals with IC<sub>50</sub> values of 180.00 μg/mL (DPPH<sup>•</sup>), 60.00 μg/mL (ABTS<sup>•+</sup>), and 164.00 μg/mL (O<sub>2</sub><sup>•</sup>), and exhibited reducing activity with an RP<sub>0.5AU</sub> value of 107.00 μg/mL. Importantly, NR extract (IC<sub>50</sub> value: 60.00 μg/mL) exhibited much higher inhibitory activity than LR extract (IC<sub>50</sub> value: 1100.00 μg/mL) in XTT assay. HPLC analysis revealed that both <i>R. maritima</i> extracts contained phenolics, such as chicoric acid, quercetin-3-<i>O</i>-glucopyranoside, <i>p</i>-coumaric acid, 3,5-dimethoxy-4-hydroxicinnanic acid, <i>trans</i>-ferulic acid, and rutin hydrate, possessing antioxidant and/or anticancer activity. Thus, the present study showed for the first time that <i>R. maritima</i> extracts from either LR or NR are a promising source of bioactive compounds having beneficial properties for human health.https://www.mdpi.com/1420-3049/30/13/2800<i>Ruppia maritima</i>brackish water angiospermseagrassantioxidantanticancerpolyphenols |
| spellingShingle | Alkistis Kevrekidou Nikolaos Goutzourelas Stavroula Savvidi Varvara Trachana Andreana N. Assimopoulou Ming Liu Paraskevi Malea Dimitrios Stagos Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i> Molecules <i>Ruppia maritima</i> brackish water angiosperm seagrass antioxidant anticancer polyphenols |
| title | Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i> |
| title_full | Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i> |
| title_fullStr | Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i> |
| title_full_unstemmed | Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i> |
| title_short | Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i> |
| title_sort | comparison of polyphenolic content and bioactivities between extracts from the living plants and beach deposits of the submerged brackish water angiosperm i ruppia maritima i |
| topic | <i>Ruppia maritima</i> brackish water angiosperm seagrass antioxidant anticancer polyphenols |
| url | https://www.mdpi.com/1420-3049/30/13/2800 |
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