Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i>

Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm <i>Ruppia maritima</i>

Bioactive extracts from living plants (LR) and beach deposits (NR) of the submerged brackish water angiosperm <i>Ruppia maritima</i> were examined for their antioxidant activity and anticancer potential. LR extract scavenged effectively free radicals with IC<sub>50</sub> valu...

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Main Authors: Alkistis Kevrekidou, Nikolaos Goutzourelas, Stavroula Savvidi, Varvara Trachana, Andreana N. Assimopoulou, Ming Liu, Paraskevi Malea, Dimitrios Stagos
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
<i>Ruppia maritima</i>
brackish water angiosperm
seagrass
antioxidant
anticancer
polyphenols
Online Access:https://www.mdpi.com/1420-3049/30/13/2800
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Summary:Bioactive extracts from living plants (LR) and beach deposits (NR) of the submerged brackish water angiosperm <i>Ruppia maritima</i> were examined for their antioxidant activity and anticancer potential. LR extract scavenged effectively free radicals with IC<sub>50</sub> values of 38.00 μg/mL (DPPH<sup>•</sup>), 12.00 μg/mL (ABTS<sup>•+</sup>), 281.00 μg/mL (OH<sup>•</sup>), and 53.00 μg/mL (O<sub>2</sub><sup>•</sup>), and exhibited reducing activity with an RP<sub>0.5AU</sub> value of 37.00 μg/mL. NR extract retained a significant part of LR extract’s antioxidant activity by scavenging free radicals with IC<sub>50</sub> values of 180.00 μg/mL (DPPH<sup>•</sup>), 60.00 μg/mL (ABTS<sup>•+</sup>), and 164.00 μg/mL (O<sub>2</sub><sup>•</sup>), and exhibited reducing activity with an RP<sub>0.5AU</sub> value of 107.00 μg/mL. Importantly, NR extract (IC<sub>50</sub> value: 60.00 μg/mL) exhibited much higher inhibitory activity than LR extract (IC<sub>50</sub> value: 1100.00 μg/mL) in XTT assay. HPLC analysis revealed that both <i>R. maritima</i> extracts contained phenolics, such as chicoric acid, quercetin-3-<i>O</i>-glucopyranoside, <i>p</i>-coumaric acid, 3,5-dimethoxy-4-hydroxicinnanic acid, <i>trans</i>-ferulic acid, and rutin hydrate, possessing antioxidant and/or anticancer activity. Thus, the present study showed for the first time that <i>R. maritima</i> extracts from either LR or NR are a promising source of bioactive compounds having beneficial properties for human health.
ISSN:1420-3049

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