Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report
Modern pathogenetic therapy of idiopathic pulmonary arterial hypertension (IPAH), a severe life-threatening cardiovascular disease of unknown etiology, leads to a positive clinical effect due to reverse remodeling of the vessels of the microvasculature of the lungs. Highly effective drugs of specifi...
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| Format: | Article |
| Language: | Russian |
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InterMedservice
2022-12-01
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| Series: | Евразийский Кардиологический Журнал |
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| Online Access: | https://www.heartj.asia/jour/article/view/6353 |
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| author | S. A. Musashaykhova Z. S. Valieva A. K. Osokina I. Z. Korobkova V. V. Gramovich N. M. Danilov T. V. Martynyuk |
| author_facet | S. A. Musashaykhova Z. S. Valieva A. K. Osokina I. Z. Korobkova V. V. Gramovich N. M. Danilov T. V. Martynyuk |
| author_sort | S. A. Musashaykhova |
| collection | DOAJ |
| description | Modern pathogenetic therapy of idiopathic pulmonary arterial hypertension (IPAH), a severe life-threatening cardiovascular disease of unknown etiology, leads to a positive clinical effect due to reverse remodeling of the vessels of the microvasculature of the lungs. Highly effective drugs of specific therapy that act on the main targets of pathogenesis have now been introduced into clinical practice.The presented clinical case of a patient with diagnosed in 2014 IPAH with an initial functional class III according to the WHO classification demonstrates high long-term efficacy and safety of specific therapy based on the use of the soluble guanylate cyclase stimulator riociguat for 5 years after replacing previous therapy with sildenafil with further implementation of the strategy of sequential combination therapy due to the addition of ambrisentan and selexipag. |
| format | Article |
| id | doaj-art-c863d9d7f08d4d9791a8af2cbbb45589 |
| institution | Kabale University |
| issn | 2225-1685 2305-0748 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | InterMedservice |
| record_format | Article |
| series | Евразийский Кардиологический Журнал |
| spelling | doaj-art-c863d9d7f08d4d9791a8af2cbbb455892025-08-20T03:58:59ZrusInterMedserviceЕвразийский Кардиологический Журнал2225-16852305-07482022-12-0104748110.38109/2225-1685-2022-4-74-816284Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case reportS. A. Musashaykhova0Z. S. Valieva1A. K. Osokina2I. Z. Korobkova3V. V. Gramovich4N. M. Danilov5T. V. Martynyuk6A.L. Myasnikov Research Institute of Clinical Cardiology, E.I. Chazov National Medical Research Centre of СardiologyA.L. Myasnikov Research Institute of Clinical Cardiology, E.I. Chazov National Medical Research Centre of СardiologyA.L. Myasnikov Research Institute of Clinical Cardiology, E.I. Chazov National Medical Research Centre of СardiologyA.L. Myasnikov Research Institute of Clinical Cardiology, E.I. Chazov National Medical Research Centre of Сardiology; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of RussiaA.L. Myasnikov Research Institute of Clinical Cardiology, E.I. Chazov National Medical Research Centre of СardiologyA.L. Myasnikov Research Institute of Clinical Cardiology, E.I. Chazov National Medical Research Centre of СardiologyA.L. Myasnikov Research Institute of Clinical Cardiology, E.I. Chazov National Medical Research Centre of Сardiology; N.I. Pirogov Russian National Research Medical UniversityModern pathogenetic therapy of idiopathic pulmonary arterial hypertension (IPAH), a severe life-threatening cardiovascular disease of unknown etiology, leads to a positive clinical effect due to reverse remodeling of the vessels of the microvasculature of the lungs. Highly effective drugs of specific therapy that act on the main targets of pathogenesis have now been introduced into clinical practice.The presented clinical case of a patient with diagnosed in 2014 IPAH with an initial functional class III according to the WHO classification demonstrates high long-term efficacy and safety of specific therapy based on the use of the soluble guanylate cyclase stimulator riociguat for 5 years after replacing previous therapy with sildenafil with further implementation of the strategy of sequential combination therapy due to the addition of ambrisentan and selexipag.https://www.heartj.asia/jour/article/view/6353idiopathic pulmonary arterial hypertensionspecific therapysildenafilriociguatambrisentanselexipagcase report |
| spellingShingle | S. A. Musashaykhova Z. S. Valieva A. K. Osokina I. Z. Korobkova V. V. Gramovich N. M. Danilov T. V. Martynyuk Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report Евразийский Кардиологический Журнал idiopathic pulmonary arterial hypertension specific therapy sildenafil riociguat ambrisentan selexipag case report |
| title | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_full | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_fullStr | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_full_unstemmed | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_short | Possibilities of long-term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy: case report |
| title_sort | possibilities of long term effective treatment of idiopathic pulmonary arterial hypertension by replacing sildenafil with riociguat and using sequential combination therapy case report |
| topic | idiopathic pulmonary arterial hypertension specific therapy sildenafil riociguat ambrisentan selexipag case report |
| url | https://www.heartj.asia/jour/article/view/6353 |
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