CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation

CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation

Abstract Background Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder, which is characterized by a decline in cognitive abilities. Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most im...

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Bibliographic Details
Main Authors: Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
CD2AP
P38 MAPK
Synaptic injury
Tau
Online Access:https://doi.org/10.1186/s40035-024-00454-5
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