Proximity Labeling and Genetic Screening Reveal that DSG2 is a Counter Receptor of Siglec‐9 and Suppresses Macrophage Phagocytosis

Proximity Labeling and Genetic Screening Reveal that DSG2 is a Counter Receptor of Siglec‐9 and Suppresses Macrophage Phagocytosis

Abstract Cancer cells present sialylated glycoconjugates that modulate the activity of various immune cells within the tumor microenvironment through trans interaction with immunosuppressive Siglec receptors. Identifying counter receptors for Siglecs can provide valuable targets for cancer immunothe...

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Bibliographic Details
Main Authors:	Ying Wu, Yuyu You, Tingsong Jiang, Yuqi He, Qingchi Fan, Xinlei Zeng, Ting Li, Yuxing Lu, Liang Qi, Fengxia Zhou, Lingyu Sun, Danyang Wang, Yong Zou, Guigen Zhang, Yanqiu Yuan, Yang Mao
Format:	Article
Language:	English
Published:	Wiley 2025-03-01
Series:	Advanced Science
Subjects:	DSG2 genetic screening phagocytosis proximity labeling siglec‐9
Online Access:	https://doi.org/10.1002/advs.202406654
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