Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy
Objective To correlate structural features seen on optical coherence tomography (OCT) with best-corrected visual acuity (BCVA) and Gass lesion type in patients with Best vitelliform macular dystrophy (BVMD).Methods and analysis This is a retrospective case series of consecutive patients with molecul...
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BMJ Publishing Group
2021-09-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/6/1/e000860.full |
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| author | Elliott H Sohn EDWIN M STONE Razek G Coussa Christopher R Fortenbach D Brice Critser Malia M Collins Budd A Tucker Robert F Mullins Ian C Han |
| author_facet | Elliott H Sohn EDWIN M STONE Razek G Coussa Christopher R Fortenbach D Brice Critser Malia M Collins Budd A Tucker Robert F Mullins Ian C Han |
| author_sort | Elliott H Sohn |
| collection | DOAJ |
| description | Objective To correlate structural features seen on optical coherence tomography (OCT) with best-corrected visual acuity (BCVA) and Gass lesion type in patients with Best vitelliform macular dystrophy (BVMD).Methods and analysis This is a retrospective case series of consecutive patients with molecularly confirmed BEST1-associated BVMD. OCT scans were reviewed for lesion status and presence of subretinal pillar, focal choroidal excavation (FCE), intraretinal fluid or atrophy. Available OCT angiography images were used to evaluate for the presence of choroidal neovascularisation (CNV). These features were then correlated with BCVA and Gass lesion type.Results 95 eyes from 48 patients (mean age 38.9 years, range 4–87) were included. The presence of a pillar (24.2%), FCE (20.0%) and atrophy (7.4%) were associated with poor BCVA (p<0.05). Gass lesion type 1 eyes were correlated with good BCVA (LogMAR <0.4) whereas type 5 eyes had poor BCVA (LogMAR >0.4). Among 65 eyes with longitudinal data (mean follow-up 5.1 years), 7 eyes (10.8%) reverted from higher to lower Gass lesion type; of these, 4 eyes (57.1%) had CNV responsive to intravitreal anti-vascular endothelial growth factor treatment.Conclusion OCT-based structural features are readily identifiable in patients with BVMD and have prognostic importance due to their correlation with BCVA. |
| format | Article |
| id | doaj-art-c8521434257a4c199550d56d376c841b |
| institution | OA Journals |
| issn | 2397-3269 |
| language | English |
| publishDate | 2021-09-01 |
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| series | BMJ Open Ophthalmology |
| spelling | doaj-art-c8521434257a4c199550d56d376c841b2025-08-20T02:11:35ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692021-09-016110.1136/bmjophth-2021-000860Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophyElliott H Sohn0EDWIN M STONE1Razek G Coussa2Christopher R Fortenbach3D Brice Critser4Malia M Collins5Budd A Tucker6Robert F Mullins7Ian C Han8Institute for Vision Research, University of Iowa Carver College of Medicine, Iowa City, Iowa, USADepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USADepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USAInstitute for Vision Research, University of Iowa, Iowa City, Iowa, USADepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USADepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USADepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USADepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USADepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USAObjective To correlate structural features seen on optical coherence tomography (OCT) with best-corrected visual acuity (BCVA) and Gass lesion type in patients with Best vitelliform macular dystrophy (BVMD).Methods and analysis This is a retrospective case series of consecutive patients with molecularly confirmed BEST1-associated BVMD. OCT scans were reviewed for lesion status and presence of subretinal pillar, focal choroidal excavation (FCE), intraretinal fluid or atrophy. Available OCT angiography images were used to evaluate for the presence of choroidal neovascularisation (CNV). These features were then correlated with BCVA and Gass lesion type.Results 95 eyes from 48 patients (mean age 38.9 years, range 4–87) were included. The presence of a pillar (24.2%), FCE (20.0%) and atrophy (7.4%) were associated with poor BCVA (p<0.05). Gass lesion type 1 eyes were correlated with good BCVA (LogMAR <0.4) whereas type 5 eyes had poor BCVA (LogMAR >0.4). Among 65 eyes with longitudinal data (mean follow-up 5.1 years), 7 eyes (10.8%) reverted from higher to lower Gass lesion type; of these, 4 eyes (57.1%) had CNV responsive to intravitreal anti-vascular endothelial growth factor treatment.Conclusion OCT-based structural features are readily identifiable in patients with BVMD and have prognostic importance due to their correlation with BCVA.https://bmjophth.bmj.com/content/6/1/e000860.full |
| spellingShingle | Elliott H Sohn EDWIN M STONE Razek G Coussa Christopher R Fortenbach D Brice Critser Malia M Collins Budd A Tucker Robert F Mullins Ian C Han Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy BMJ Open Ophthalmology |
| title | Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy |
| title_full | Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy |
| title_fullStr | Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy |
| title_full_unstemmed | Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy |
| title_short | Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy |
| title_sort | correlation of features on oct with visual acuity and gass lesion type in best vitelliform macular dystrophy |
| url | https://bmjophth.bmj.com/content/6/1/e000860.full |
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