Assessment of the Degree of Left Atrial Fibrosis in Patients with Different Forms of Atrial Fibrillation
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, which has a significant impact on the health of patients worldwide. Left atrial fibrosis (LAF) is considered an irreversible form of remodeling that occurs in response to inflammation, stretching, or overload of the left atrium....
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Professional Edition Eastern Europe
2025-06-01
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| Series: | Український журнал серцево-судинної хірургії |
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| Online Access: | https://cvs.org.ua/index.php/ujcvs/article/view/732 |
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| author | Eugene O. Perepeka Elina V. Bodnarevska Mykhailo S. Ishchenko Borys B. Kravchuk |
| author_facet | Eugene O. Perepeka Elina V. Bodnarevska Mykhailo S. Ishchenko Borys B. Kravchuk |
| author_sort | Eugene O. Perepeka |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, which has a significant impact on the health of patients worldwide. Left atrial fibrosis (LAF) is considered an irreversible form of remodeling that occurs in response to inflammation, stretching, or overload of the left atrium. The prevalence and degree of LAF may be associated with the prognosis and treatment outcomes after catheter ablation.
Aim. To determine whether the degree of left atrial fibrosis is associated with the progression of atrial fibrillation.
Materials and methods. During the period from January 2023 to December 2024, the State Research Institute of Cardiology named after M.M. Amosov National Academy of Medical Sciences of Ukraine performed 58 MRI studies with late contrast enhancement with gadolinium to study the degree of fibrosis of different chambers of the heart. Thirty-six of these patients were diagnosed with AF. In 12 patients, catheter ablation for atrial fibrillation was subsequently performed (radiofrequency, cryoballoon ablation, or pulsed field ablation). In 10, an attempt at electrical cardioversion without catheter intervention was performed.
Results. Among the 34 patients included in the study, 13 (38 %) had paroxysmal AF, 14 (41 %) had persistent AF, and 7 (21 %) had permanent AF. Among the patients with paroxysmal AF, 9 (69 %) had stage I of left atrial fibrosis (LAF), 4 (31 %) had LAF stage II. No patients with LAF stage III-IV were observed in the paroxysmal AF group. In the persistent AF group (n = 14, 41 %), LAF stage I was observed in 4 (29 %) patients, LAF stage II in 8 (57 %), and LAF stage III and IV in 1 (7 %) patient in each group. In the patients with permanent AF (n = 7, 21 %), no patients with LAF stage I were observed. LAF stage II was observed in 4 (57 %) patients, LAF stage III in 2 (28 %), and LAF stage IV in 1 (14 %). The analysis showed a statistically significant decrease in left ventricular ejection fraction in patients with progressive AF. In the paroxysmal group, the mean LVEF was 55.75 ± 11.05 %, while in patients with persistent AF it decreased to 47.46 ± 13.88 %, and in chronic AF it decreased to 36.29 ± 12.08 % (p = 0.018).
Conclusions. According to our results, the degree of fibrosis of the left atrium correlates with the stage of progression of atrial fibrillation. |
| format | Article |
| id | doaj-art-c85213f979cd48b784a26c5860352113 |
| institution | Kabale University |
| issn | 2664-5963 2664-5971 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Professional Edition Eastern Europe |
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| series | Український журнал серцево-судинної хірургії |
| spelling | doaj-art-c85213f979cd48b784a26c58603521132025-08-20T03:29:38ZengProfessional Edition Eastern EuropeУкраїнський журнал серцево-судинної хірургії2664-59632664-59712025-06-01332626910.63181/ujcvs.2025.33(2).62-69732Assessment of the Degree of Left Atrial Fibrosis in Patients with Different Forms of Atrial FibrillationEugene O. Perepeka0https://orcid.org/0000-0001-9755-8825Elina V. Bodnarevska1https://orcid.org/0009-0001-0019-7195Mykhailo S. Ishchenko2https://orcid.org/0000-0002-4166-7173Borys B. Kravchuk3https://orcid.org/0000-0002-4535-7797National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine, Kyiv, UkraineNational Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine, Kyiv, UkraineNational Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine, Kyiv, UkraineNational Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine, Kyiv, UkraineAtrial fibrillation (AF) is the most common type of cardiac arrhythmia, which has a significant impact on the health of patients worldwide. Left atrial fibrosis (LAF) is considered an irreversible form of remodeling that occurs in response to inflammation, stretching, or overload of the left atrium. The prevalence and degree of LAF may be associated with the prognosis and treatment outcomes after catheter ablation. Aim. To determine whether the degree of left atrial fibrosis is associated with the progression of atrial fibrillation. Materials and methods. During the period from January 2023 to December 2024, the State Research Institute of Cardiology named after M.M. Amosov National Academy of Medical Sciences of Ukraine performed 58 MRI studies with late contrast enhancement with gadolinium to study the degree of fibrosis of different chambers of the heart. Thirty-six of these patients were diagnosed with AF. In 12 patients, catheter ablation for atrial fibrillation was subsequently performed (radiofrequency, cryoballoon ablation, or pulsed field ablation). In 10, an attempt at electrical cardioversion without catheter intervention was performed. Results. Among the 34 patients included in the study, 13 (38 %) had paroxysmal AF, 14 (41 %) had persistent AF, and 7 (21 %) had permanent AF. Among the patients with paroxysmal AF, 9 (69 %) had stage I of left atrial fibrosis (LAF), 4 (31 %) had LAF stage II. No patients with LAF stage III-IV were observed in the paroxysmal AF group. In the persistent AF group (n = 14, 41 %), LAF stage I was observed in 4 (29 %) patients, LAF stage II in 8 (57 %), and LAF stage III and IV in 1 (7 %) patient in each group. In the patients with permanent AF (n = 7, 21 %), no patients with LAF stage I were observed. LAF stage II was observed in 4 (57 %) patients, LAF stage III in 2 (28 %), and LAF stage IV in 1 (14 %). The analysis showed a statistically significant decrease in left ventricular ejection fraction in patients with progressive AF. In the paroxysmal group, the mean LVEF was 55.75 ± 11.05 %, while in patients with persistent AF it decreased to 47.46 ± 13.88 %, and in chronic AF it decreased to 36.29 ± 12.08 % (p = 0.018). Conclusions. According to our results, the degree of fibrosis of the left atrium correlates with the stage of progression of atrial fibrillation.https://cvs.org.ua/index.php/ujcvs/article/view/732catheter ablationcryoballoon ablationheart failureatrial cardiomyopathyelectrical cardioversionpulsed field ablationpacemaker |
| spellingShingle | Eugene O. Perepeka Elina V. Bodnarevska Mykhailo S. Ishchenko Borys B. Kravchuk Assessment of the Degree of Left Atrial Fibrosis in Patients with Different Forms of Atrial Fibrillation Український журнал серцево-судинної хірургії catheter ablation cryoballoon ablation heart failure atrial cardiomyopathy electrical cardioversion pulsed field ablation pacemaker |
| title | Assessment of the Degree of Left Atrial Fibrosis in Patients with Different Forms of Atrial Fibrillation |
| title_full | Assessment of the Degree of Left Atrial Fibrosis in Patients with Different Forms of Atrial Fibrillation |
| title_fullStr | Assessment of the Degree of Left Atrial Fibrosis in Patients with Different Forms of Atrial Fibrillation |
| title_full_unstemmed | Assessment of the Degree of Left Atrial Fibrosis in Patients with Different Forms of Atrial Fibrillation |
| title_short | Assessment of the Degree of Left Atrial Fibrosis in Patients with Different Forms of Atrial Fibrillation |
| title_sort | assessment of the degree of left atrial fibrosis in patients with different forms of atrial fibrillation |
| topic | catheter ablation cryoballoon ablation heart failure atrial cardiomyopathy electrical cardioversion pulsed field ablation pacemaker |
| url | https://cvs.org.ua/index.php/ujcvs/article/view/732 |
| work_keys_str_mv | AT eugeneoperepeka assessmentofthedegreeofleftatrialfibrosisinpatientswithdifferentformsofatrialfibrillation AT elinavbodnarevska assessmentofthedegreeofleftatrialfibrosisinpatientswithdifferentformsofatrialfibrillation AT mykhailosishchenko assessmentofthedegreeofleftatrialfibrosisinpatientswithdifferentformsofatrialfibrillation AT borysbkravchuk assessmentofthedegreeofleftatrialfibrosisinpatientswithdifferentformsofatrialfibrillation |