Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis
RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/6195258 |
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| author | Alexandra Cornelia Teodorescu Ioana Martu Silvia Teslaru Diana Cristala Kappenberg-Nitescu Ancuta Goriuc Ionut Luchian Maria Alexandra Martu Sorina Mihaela Solomon Silvia Mârțu |
| author_facet | Alexandra Cornelia Teodorescu Ioana Martu Silvia Teslaru Diana Cristala Kappenberg-Nitescu Ancuta Goriuc Ionut Luchian Maria Alexandra Martu Sorina Mihaela Solomon Silvia Mârțu |
| author_sort | Alexandra Cornelia Teodorescu |
| collection | DOAJ |
| description | RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, the RANKL is available to bond with RANK (receptor activator of nuclear factor kappa-β). This study was conducted on 41 patients: 19 with generalized aggressive periodontitis, 18 with severe chronic periodontitis, and 4 periodontal healthy subjects. For each patient included, we determined the salivary levels of RANKL and OPG with the help of two Human ELISA kits. The results show that the patients affected by periodontitis, either aggressive or chronic, have significant higher values of RANKL and RANKL/OPG ratio. This values correlate with the local inflammation status. |
| format | Article |
| id | doaj-art-c84b9a3f3d5e415399c0bfdb49be8bed |
| institution | DOAJ |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c84b9a3f3d5e415399c0bfdb49be8bed2025-08-20T03:23:57ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/61952586195258Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic PeriodontitisAlexandra Cornelia Teodorescu0Ioana Martu1Silvia Teslaru2Diana Cristala Kappenberg-Nitescu3Ancuta Goriuc4Ionut Luchian5Maria Alexandra Martu6Sorina Mihaela Solomon7Silvia Mârțu8Grigore T. Popa University of Medicine and Pharmacy Iasi, Faculty of Dental Medicine, 16 Universității Str., 700115, RomaniaGrigore T. Popa University of Medicine and Pharmacy Iasi, Faculty of Dental Medicine, 16 Universității Str., 700115, RomaniaGrigore T. Popa University of Medicine and Pharmacy Iasi, Faculty of Dental Medicine, 16 Universității Str., 700115, RomaniaGrigore T. Popa University of Medicine and Pharmacy Iasi, Faculty of Dental Medicine, 16 Universității Str., 700115, RomaniaGrigore T. Popa University of Medicine and Pharmacy Iasi, Faculty of Dental Medicine, 16 Universității Str., 700115, RomaniaGrigore T. Popa University of Medicine and Pharmacy Iasi, Faculty of Dental Medicine, 16 Universității Str., 700115, RomaniaGrigore T. Popa University of Medicine and Pharmacy Iasi, Faculty of Dental Medicine, 16 Universității Str., 700115, RomaniaGrigore T. Popa University of Medicine and Pharmacy Iasi, Faculty of Dental Medicine, 16 Universității Str., 700115, RomaniaGrigore T. Popa University of Medicine and Pharmacy Iasi, Faculty of Dental Medicine, 16 Universității Str., 700115, RomaniaRANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, the RANKL is available to bond with RANK (receptor activator of nuclear factor kappa-β). This study was conducted on 41 patients: 19 with generalized aggressive periodontitis, 18 with severe chronic periodontitis, and 4 periodontal healthy subjects. For each patient included, we determined the salivary levels of RANKL and OPG with the help of two Human ELISA kits. The results show that the patients affected by periodontitis, either aggressive or chronic, have significant higher values of RANKL and RANKL/OPG ratio. This values correlate with the local inflammation status.http://dx.doi.org/10.1155/2019/6195258 |
| spellingShingle | Alexandra Cornelia Teodorescu Ioana Martu Silvia Teslaru Diana Cristala Kappenberg-Nitescu Ancuta Goriuc Ionut Luchian Maria Alexandra Martu Sorina Mihaela Solomon Silvia Mârțu Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis Journal of Immunology Research |
| title | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
| title_full | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
| title_fullStr | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
| title_full_unstemmed | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
| title_short | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
| title_sort | assessment of salivary levels of rankl and opg in aggressive versus chronic periodontitis |
| url | http://dx.doi.org/10.1155/2019/6195258 |
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