Blood–brain barrier disruption and neuroinflammation in the hippocampus of a cardiac arrest porcine model: Single-cell RNA sequencing analysis

Blood–brain barrier disruption and neuroinflammation in the hippocampus of a cardiac arrest porcine model: Single-cell RNA sequencing analysis

Global brain ischemia and neurological deficit are consequences of cardiac arrest that lead to high mortality. Despite advancements in resuscitation science, our limited understanding of the cellular and molecular mechanisms underlying post-cardiac arrest brain injury have hindered the development o...

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Main Authors: Tangxing Jiang, Yaning Li, Hehui Liu, Yijun Sun, Huidan Zhang, Qirui Zhang, Shuyao Tang, Xu Niu, Han Du, Yinxia Yu, Hongwei Yue, Yunyun Guo, Yuguo Chen, Feng Xu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-02-01
Series:Neural Regeneration Research
Subjects:
blood–brain barrier disruption
cardiac arrest
hippocampus
microglia
neuroinflammation
neuroprotection
neutrophil
oligodendrocyte dysfunction
s100a8
single-cell rna sequencing
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-01269
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