A Tissue-Engineered Construct Based on a Decellularized Scaffold and the Islets of Langerhans: A Streptozotocin-Induced Diabetic Model

A Tissue-Engineered Construct Based on a Decellularized Scaffold and the Islets of Langerhans: A Streptozotocin-Induced Diabetic Model

Producing a tissue-engineered pancreas based on a tissue-specific scaffold from a decellularized pancreas, imitating the natural pancreatic tissue microenvironment and the islets of Langerhans, is one of the approaches to treating patients with type 1 diabetes mellitus (T1DM). The aim of this work w...

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Main Authors: Victor I. Sevastianov, Anna S. Ponomareva, Natalia V. Baranova, Aleksandra D. Belova, Lyudmila A. Kirsanova, Alla O. Nikolskaya, Eugenia G. Kuznetsova, Elizaveta O. Chuykova, Nikolay N. Skaletskiy, Galina N. Skaletskaya, Evgeniy A. Nemets, Yulia B. Basok, Sergey V. Gautier
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Life
Subjects:
decellularized scaffold
streptozotocin-induced diabetes mellitus
islets of Langerhans
islet transplantation
Online Access:https://www.mdpi.com/2075-1729/14/11/1505
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