Quantification and correlation of amyloid-β plaque load, glial activation, GABAergic interneuron numbers, and cognitive decline in the young TgF344-AD rat model of Alzheimer’s disease

Quantification and correlation of amyloid-β plaque load, glial activation, GABAergic interneuron numbers, and cognitive decline in the young TgF344-AD rat model of Alzheimer’s disease

BackgroundAnimal models of Alzheimer’s disease (AD) are essential tools for investigating disease pathophysiology and conducting preclinical drug testing. In this study, we examined neuronal and glial alterations in the hippocampus and medial prefrontal cortex (mPFC) of young TgF344-AD rats and corr...

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Main Authors: Anett Futácsi, Kitti Rusznák, Gergely Szarka, Béla Völgyi, Ove Wiborg, Boldizsár Czéh
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
astrocyte
Barnes maze
cell number
cholecystokinin
hippocampus
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1542229/full
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