Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats
We have built a rat’s model to investigate whether the hypothermia induced by adenosine 5′-monophosphate (5′-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed the p...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/459617 |
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| _version_ | 1849684023752785920 |
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| author | Zhimin Miao Shulai Lu Na Du Weiting Guo Jidong Zhang Yu Song Xuefeng Wang Wei Ren Yunlong Wang Tao Jiang |
| author_facet | Zhimin Miao Shulai Lu Na Du Weiting Guo Jidong Zhang Yu Song Xuefeng Wang Wei Ren Yunlong Wang Tao Jiang |
| author_sort | Zhimin Miao |
| collection | DOAJ |
| description | We have built a rat’s model to investigate whether the hypothermia induced by adenosine 5′-monophosphate (5′-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed the pathological changes in the lungs. We have found that AIH can effectively inhibit acute inflammatory reactions and protect the lung from acute injury induced by LPS in rats. |
| format | Article |
| id | doaj-art-c82fd214a431439b910bfdbb9281989f |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c82fd214a431439b910bfdbb9281989f2025-08-20T03:23:35ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/459617459617Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in RatsZhimin Miao0Shulai Lu1Na Du2Weiting Guo3Jidong Zhang4Yu Song5Xuefeng Wang6Wei Ren7Yunlong Wang8Tao Jiang9Gout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, ChinaStomatological Department, Qingdao Municipal Hospital, Qingdao 266011, ChinaKey Laboratory of Marine Drugs, School of Pharmacy, Ocean University of China, Ministry of Education of China, Qingdao 266003, ChinaGout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, ChinaDepartment of Cardiology, The Affiliated Hospital of Medical College Qingdao University, Qingdao 266011, ChinaStomatological Department, Qingdao Municipal Hospital, Qingdao 266011, ChinaGout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, ChinaGout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, ChinaGout Laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory of Metabolic Diseases, 16 Jiangsu Road, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, School of Pharmacy, Ocean University of China, Ministry of Education of China, Qingdao 266003, ChinaWe have built a rat’s model to investigate whether the hypothermia induced by adenosine 5′-monophosphate (5′-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed the pathological changes in the lungs. We have found that AIH can effectively inhibit acute inflammatory reactions and protect the lung from acute injury induced by LPS in rats.http://dx.doi.org/10.1155/2012/459617 |
| spellingShingle | Zhimin Miao Shulai Lu Na Du Weiting Guo Jidong Zhang Yu Song Xuefeng Wang Wei Ren Yunlong Wang Tao Jiang Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats Mediators of Inflammation |
| title | Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats |
| title_full | Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats |
| title_fullStr | Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats |
| title_full_unstemmed | Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats |
| title_short | Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats |
| title_sort | hypothermia induced by adenosine 5 monophosphate attenuates acute lung injury induced by lps in rats |
| url | http://dx.doi.org/10.1155/2012/459617 |
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