Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report
Abstract Background When diagnosing patients with bilateral breast cancer, it is challenging to determine the relationship between multiple breast cancer lesions at the individual patient level with certainty. Case presentation A 35-year-old Japanese woman was diagnosed with a left breast cancer. Sh...
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Japan Surgical Society
2020-08-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-020-00966-y |
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| author | Yoshiaki Shinden Hazuki Saho Yuki Nomoto Ayako Nagata Koji Minami Akihiro Nakajo Toshiaki Akahane Tsubasa Hiraki Akihide Tanimoto Tetsuhiro Owaki Yuko Kijima Shoji Natsugoe |
| author_facet | Yoshiaki Shinden Hazuki Saho Yuki Nomoto Ayako Nagata Koji Minami Akihiro Nakajo Toshiaki Akahane Tsubasa Hiraki Akihide Tanimoto Tetsuhiro Owaki Yuko Kijima Shoji Natsugoe |
| author_sort | Yoshiaki Shinden |
| collection | DOAJ |
| description | Abstract Background When diagnosing patients with bilateral breast cancer, it is challenging to determine the relationship between multiple breast cancer lesions at the individual patient level with certainty. Case presentation A 35-year-old Japanese woman was diagnosed with a left breast cancer. She was previously diagnosed with right pT3N3M0 stage IIIC breast cancer and underwent chemotherapy with targeted therapy, radiotherapy, and endocrine therapy as adjuvant treatment after mastectomy and axillary lymph node dissection. Approximately 2 years after the first surgery, her left breast cancer was preoperatively diagnosed as a contralateral primary breast cancer, and left mastectomy and axillary lymph node dissection were performed. Histopathologically, the tumor was determined to be invasive ductal carcinoma accompanied with several intraductal components. After a second surgery, mutation analysis of her bilateral breast cancer was performed in a clinical study, which revealed that her metachronous bilateral breast tumors had the same GATA3 and CSMD1 mutations. Thus, mutation analysis strongly supported her latter left breast cancer being a metastatic lesion from the former right breast cancer. Some difficulties in diagnosing bilateral breast cancer exist when determining whether they are double primary cancers or represent contralateral breast metastasis. The existence of intraductal components is a critical piece of information for suspecting primary lesions. However, this case demonstrated that metastatic contralateral breast lesions can have intraductal components. Conclusion Herein we report a genetically proven contralateral breast metastasis with some intraductal components. |
| format | Article |
| id | doaj-art-c82ea60e049f488e90a222cb502ed28e |
| institution | DOAJ |
| issn | 2198-7793 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-c82ea60e049f488e90a222cb502ed28e2025-08-20T02:54:42ZengJapan Surgical SocietySurgical Case Reports2198-77932020-08-01611610.1186/s40792-020-00966-yBreast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case reportYoshiaki Shinden0Hazuki Saho1Yuki Nomoto2Ayako Nagata3Koji Minami4Akihiro Nakajo5Toshiaki Akahane6Tsubasa Hiraki7Akihide Tanimoto8Tetsuhiro Owaki9Yuko Kijima10Shoji Natsugoe11Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Pathology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Pathology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Pathology, Kagoshima University Graduate School of Medical and Dental SciencesEducation Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Breast Surgery, School of Medicine, Fujita Health UniversityDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental SciencesAbstract Background When diagnosing patients with bilateral breast cancer, it is challenging to determine the relationship between multiple breast cancer lesions at the individual patient level with certainty. Case presentation A 35-year-old Japanese woman was diagnosed with a left breast cancer. She was previously diagnosed with right pT3N3M0 stage IIIC breast cancer and underwent chemotherapy with targeted therapy, radiotherapy, and endocrine therapy as adjuvant treatment after mastectomy and axillary lymph node dissection. Approximately 2 years after the first surgery, her left breast cancer was preoperatively diagnosed as a contralateral primary breast cancer, and left mastectomy and axillary lymph node dissection were performed. Histopathologically, the tumor was determined to be invasive ductal carcinoma accompanied with several intraductal components. After a second surgery, mutation analysis of her bilateral breast cancer was performed in a clinical study, which revealed that her metachronous bilateral breast tumors had the same GATA3 and CSMD1 mutations. Thus, mutation analysis strongly supported her latter left breast cancer being a metastatic lesion from the former right breast cancer. Some difficulties in diagnosing bilateral breast cancer exist when determining whether they are double primary cancers or represent contralateral breast metastasis. The existence of intraductal components is a critical piece of information for suspecting primary lesions. However, this case demonstrated that metastatic contralateral breast lesions can have intraductal components. Conclusion Herein we report a genetically proven contralateral breast metastasis with some intraductal components.http://link.springer.com/article/10.1186/s40792-020-00966-yBilateral breast cancerMetastatic breast lesionIntraductal components |
| spellingShingle | Yoshiaki Shinden Hazuki Saho Yuki Nomoto Ayako Nagata Koji Minami Akihiro Nakajo Toshiaki Akahane Tsubasa Hiraki Akihide Tanimoto Tetsuhiro Owaki Yuko Kijima Shoji Natsugoe Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report Surgical Case Reports Bilateral breast cancer Metastatic breast lesion Intraductal components |
| title | Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report |
| title_full | Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report |
| title_fullStr | Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report |
| title_full_unstemmed | Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report |
| title_short | Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report |
| title_sort | breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer a case report |
| topic | Bilateral breast cancer Metastatic breast lesion Intraductal components |
| url | http://link.springer.com/article/10.1186/s40792-020-00966-y |
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