SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation

SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation

Abstract The transcription factor GLI1 is the main and final effector of the Hedgehog signaling pathway, which is involved in embryonic development, cell proliferation and stemness. Whether activated through canonical or non-canonical mechanisms, GLI1 aberrant activity is associated with Hedgehog-de...

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Main Authors: Fabio Bordin, Gloria Terriaca, Adriano Apostolico, Annamaria Di Fiore, Faranak Taj Mir, Sara Bellardinelli, Francesca Bufalieri, Rosa Bordone, Francesca Bellardinilli, Giuseppe Giannini, Gianluca Canettieri, Lucia Di Marcotullio, Elisabetta Ferretti, Marta Moretti, Enrico De Smaele
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02260-4
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