DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands
A new Pt(II) complex, [Pt(DIP)(LL)](NO3)2 (in which DIP is 4,7-diphenyl-1,10-phenanthroline and LL is the aliphatic dinitrogen ligand, N,N-dimethyl-trimethylenediamine), was synthesized and characterized using different physico-chemical methods. The interaction of this complex with calf thymus DNA (...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2011/525794 |
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| author | Nahid Shahabadi Soheila Kashanian Maryam Mahdavi Noorkaram Sourinejad |
| author_facet | Nahid Shahabadi Soheila Kashanian Maryam Mahdavi Noorkaram Sourinejad |
| author_sort | Nahid Shahabadi |
| collection | DOAJ |
| description | A new Pt(II) complex, [Pt(DIP)(LL)](NO3)2 (in which DIP is 4,7-diphenyl-1,10-phenanthroline and LL is the aliphatic dinitrogen ligand, N,N-dimethyl-trimethylenediamine), was synthesized and characterized using different physico-chemical methods. The interaction of this complex with calf thymus DNA (CT-DNA) was investigated by absorption, emission, circular dichroism (CD), and viscosity measurements.
The complex binds to CT-DNA in an intercalative mode. The calculated binding constant, Kb, was 6.6×104 M−1. The enthalpy and entropy changes of the reaction between the complex and CT-DNA showed that the van der Waals interactions and hydrogen bonds are the main forces in the interaction with CT-DNA. In addition, CD study showed that phenanthroline ligand insert between the base pair stack of double helical structure of DNA. It is remarkable that this complex has the ability to cleave the supercoiled plasmid. |
| format | Article |
| id | doaj-art-c82d1b3617e241f48c73b473872ccba8 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-c82d1b3617e241f48c73b473872ccba82025-02-03T05:46:08ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2011-01-01201110.1155/2011/525794525794DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen LigandsNahid Shahabadi0Soheila Kashanian1Maryam Mahdavi2Noorkaram Sourinejad3Department of Chemistry, Faculty of Science, Razi University, Kermanshah 74155, IranDepartment of Chemistry, Faculty of Science, Razi University, Kermanshah 74155, IranDepartment of Chemistry, Faculty of Science, Razi University, Kermanshah 74155, IranDepartment of Chemistry, Faculty of Science, Razi University, Kermanshah 74155, IranA new Pt(II) complex, [Pt(DIP)(LL)](NO3)2 (in which DIP is 4,7-diphenyl-1,10-phenanthroline and LL is the aliphatic dinitrogen ligand, N,N-dimethyl-trimethylenediamine), was synthesized and characterized using different physico-chemical methods. The interaction of this complex with calf thymus DNA (CT-DNA) was investigated by absorption, emission, circular dichroism (CD), and viscosity measurements. The complex binds to CT-DNA in an intercalative mode. The calculated binding constant, Kb, was 6.6×104 M−1. The enthalpy and entropy changes of the reaction between the complex and CT-DNA showed that the van der Waals interactions and hydrogen bonds are the main forces in the interaction with CT-DNA. In addition, CD study showed that phenanthroline ligand insert between the base pair stack of double helical structure of DNA. It is remarkable that this complex has the ability to cleave the supercoiled plasmid.http://dx.doi.org/10.1155/2011/525794 |
| spellingShingle | Nahid Shahabadi Soheila Kashanian Maryam Mahdavi Noorkaram Sourinejad DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands Bioinorganic Chemistry and Applications |
| title | DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands |
| title_full | DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands |
| title_fullStr | DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands |
| title_full_unstemmed | DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands |
| title_short | DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands |
| title_sort | dna interaction and dna cleavage studies of a new platinum ii complex containing aliphatic and aromatic dinitrogen ligands |
| url | http://dx.doi.org/10.1155/2011/525794 |
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