Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre–Post Intervention Study
Mechanical bowel preparation (MBP) is essential for visualisation of the colon during colonoscopy. Previous studies have identified changes in gut microbiota composition after MBP and colonoscopy. Considering the gut microbiota is increasingly implicated in psychiatry, we explored the potential impa...
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2024-09-01
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| author | Amelia J. McGuinness Martin O’Hely Douglas Stupart David Watters Samantha L. Dawson Christopher Hair Michael Berk Mohammadreza Mohebbi Amy Loughman Glenn Guest Felice N. Jacka |
| author_facet | Amelia J. McGuinness Martin O’Hely Douglas Stupart David Watters Samantha L. Dawson Christopher Hair Michael Berk Mohammadreza Mohebbi Amy Loughman Glenn Guest Felice N. Jacka |
| author_sort | Amelia J. McGuinness |
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| description | Mechanical bowel preparation (MBP) is essential for visualisation of the colon during colonoscopy. Previous studies have identified changes in gut microbiota composition after MBP and colonoscopy. Considering the gut microbiota is increasingly implicated in psychiatry, we explored the potential impact of this intervention on mood and the microbiota–gut–brain axis. We conducted a pre–post intervention study in adults, with timepoints of one week before and one month after MBP and colonoscopy. Our primary outcome was change in average Hospital Anxiety and Depression Scale depression sub-scores. We examined changes in average anxiety, stress, and quality of life scores and gut microbiota composition using 16S rRNA sequencing. We further explored associations between changes in depressive symptoms and gut microbiota and conducted post hoc analyses to explore potential effect modifiers. Average depressive symptom scores decreased one month post-procedure compared to baseline (n = 59; adjusted β = −0.64; 95%CI: −1.18, −0.11). Irritable bowel syndrome (IBS) appeared to moderate this relationship (β = 1.78; 95%CI: 0.292, 3.26); depressive symptoms increased in those with, and decreased in those without, IBS. Reduced alpha diversity, modest effects on beta-diversity, and increases in health-associated genera were observed one month post-procedure. Increases in the CLR-transformed abundances of <i>Ruminococcaceae UCG-009</i> were associated with improvements in depressive symptoms. There is preliminary evidence of a potential mental health effect of MBP and colonoscopy, particularly for those with IBS, which may be associated with changes to the gut microbiota. Further research is required to confirm these findings and their clinical relevance. |
| format | Article |
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| institution | OA Journals |
| issn | 2076-2607 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
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| series | Microorganisms |
| spelling | doaj-art-c822dfde71ec4b88a3f466117909b5d62025-08-20T02:10:57ZengMDPI AGMicroorganisms2076-26072024-09-011210196010.3390/microorganisms12101960Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre–Post Intervention StudyAmelia J. McGuinness0Martin O’Hely1Douglas Stupart2David Watters3Samantha L. Dawson4Christopher Hair5Michael Berk6Mohammadreza Mohebbi7Amy Loughman8Glenn Guest9Felice N. Jacka10The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaSchool of Medicine, Deakin University, Geelong, VIC 3220, AustraliaSchool of Medicine, Deakin University, Geelong, VIC 3220, AustraliaThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaSchool of Medicine, Deakin University, Geelong, VIC 3220, AustraliaThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaBiostatistics Unit, Faculty of Health, Deakin University, Burwood, VIC 3125, AustraliaThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaSchool of Medicine, Deakin University, Geelong, VIC 3220, AustraliaThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaMechanical bowel preparation (MBP) is essential for visualisation of the colon during colonoscopy. Previous studies have identified changes in gut microbiota composition after MBP and colonoscopy. Considering the gut microbiota is increasingly implicated in psychiatry, we explored the potential impact of this intervention on mood and the microbiota–gut–brain axis. We conducted a pre–post intervention study in adults, with timepoints of one week before and one month after MBP and colonoscopy. Our primary outcome was change in average Hospital Anxiety and Depression Scale depression sub-scores. We examined changes in average anxiety, stress, and quality of life scores and gut microbiota composition using 16S rRNA sequencing. We further explored associations between changes in depressive symptoms and gut microbiota and conducted post hoc analyses to explore potential effect modifiers. Average depressive symptom scores decreased one month post-procedure compared to baseline (n = 59; adjusted β = −0.64; 95%CI: −1.18, −0.11). Irritable bowel syndrome (IBS) appeared to moderate this relationship (β = 1.78; 95%CI: 0.292, 3.26); depressive symptoms increased in those with, and decreased in those without, IBS. Reduced alpha diversity, modest effects on beta-diversity, and increases in health-associated genera were observed one month post-procedure. Increases in the CLR-transformed abundances of <i>Ruminococcaceae UCG-009</i> were associated with improvements in depressive symptoms. There is preliminary evidence of a potential mental health effect of MBP and colonoscopy, particularly for those with IBS, which may be associated with changes to the gut microbiota. Further research is required to confirm these findings and their clinical relevance.https://www.mdpi.com/2076-2607/12/10/1960gut microbiotacolonoscopybowel preparationdepressionmicrobiota–gut–brain axis |
| spellingShingle | Amelia J. McGuinness Martin O’Hely Douglas Stupart David Watters Samantha L. Dawson Christopher Hair Michael Berk Mohammadreza Mohebbi Amy Loughman Glenn Guest Felice N. Jacka Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre–Post Intervention Study Microorganisms gut microbiota colonoscopy bowel preparation depression microbiota–gut–brain axis |
| title | Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre–Post Intervention Study |
| title_full | Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre–Post Intervention Study |
| title_fullStr | Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre–Post Intervention Study |
| title_full_unstemmed | Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre–Post Intervention Study |
| title_short | Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre–Post Intervention Study |
| title_sort | depressive symptoms and gut microbiota after bowel preparation and colonoscopy a pre post intervention study |
| topic | gut microbiota colonoscopy bowel preparation depression microbiota–gut–brain axis |
| url | https://www.mdpi.com/2076-2607/12/10/1960 |
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