Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients
Cancer stem cells (CSCs) have been reported to be critical in the initiation, maintenance, and progression of cancers. The expression of stem cell markers, such as podoplanin (PDPN), CD133, and nestin, may have been correlated with malignant progression. However, the effects of CSCs and stem cell ma...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2014/838950 |
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| author | Byung Ho Kong Ju Hyung Moon Yong-Min Huh Jin-Kyoung Shim Ji-Hyun Lee Eui-Hyun Kim Jong Hee Chang Dong-Seok Kim Yong-Kil Hong Sun Ho Kim Su-Jae Lee Seok-Gu Kang |
| author_facet | Byung Ho Kong Ju Hyung Moon Yong-Min Huh Jin-Kyoung Shim Ji-Hyun Lee Eui-Hyun Kim Jong Hee Chang Dong-Seok Kim Yong-Kil Hong Sun Ho Kim Su-Jae Lee Seok-Gu Kang |
| author_sort | Byung Ho Kong |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) have been reported to be critical in the initiation, maintenance, and progression of cancers. The expression of stem cell markers, such as podoplanin (PDPN), CD133, and nestin, may have been correlated with malignant progression. However, the effects of CSCs and stem cell markers on clinical outcomes in cancer patients remain unclear. In this study, we assessed the prognostic roles of glioma CSCs (gCSCs) isolation and stem cell markers in patients with primary glioblastoma (pGBM). A cohort of 39 patients with pGBM was separated into two groups, those positive or negative for gCSCs, and the correlation between gCSC and patient survival was evaluated. We observed significantly different cumulative survival (P=0.045) when comparing patients positive for gCSCs patients and negative for gCSC. Among the patients positive for gCSCs, we observed no significant differences in survival between those whose gCSCs were each positive or negative for PDPN, CD133, or nestin. This study strongly supports the prognostic value of gCSCs isolation on the survival of patients with pGBM. |
| format | Article |
| id | doaj-art-c81f7b2009fb41bd96f6cd895035d6e2 |
| institution | DOAJ |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-c81f7b2009fb41bd96f6cd895035d6e22025-08-20T03:19:29ZengWileyStem Cells International1687-966X1687-96782014-01-01201410.1155/2014/838950838950Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma PatientsByung Ho Kong0Ju Hyung Moon1Yong-Min Huh2Jin-Kyoung Shim3Ji-Hyun Lee4Eui-Hyun Kim5Jong Hee Chang6Dong-Seok Kim7Yong-Kil Hong8Sun Ho Kim9Su-Jae Lee10Seok-Gu Kang11Department of Medical Science, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of KoreaDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Radiology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Seoul St. Mary’s Hospital, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of KoreaDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Life Science, Hanyang University, 17 Haendang-dong, Seongdong-gu, Seoul 133-791, Republic of KoreaDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaCancer stem cells (CSCs) have been reported to be critical in the initiation, maintenance, and progression of cancers. The expression of stem cell markers, such as podoplanin (PDPN), CD133, and nestin, may have been correlated with malignant progression. However, the effects of CSCs and stem cell markers on clinical outcomes in cancer patients remain unclear. In this study, we assessed the prognostic roles of glioma CSCs (gCSCs) isolation and stem cell markers in patients with primary glioblastoma (pGBM). A cohort of 39 patients with pGBM was separated into two groups, those positive or negative for gCSCs, and the correlation between gCSC and patient survival was evaluated. We observed significantly different cumulative survival (P=0.045) when comparing patients positive for gCSCs patients and negative for gCSC. Among the patients positive for gCSCs, we observed no significant differences in survival between those whose gCSCs were each positive or negative for PDPN, CD133, or nestin. This study strongly supports the prognostic value of gCSCs isolation on the survival of patients with pGBM.http://dx.doi.org/10.1155/2014/838950 |
| spellingShingle | Byung Ho Kong Ju Hyung Moon Yong-Min Huh Jin-Kyoung Shim Ji-Hyun Lee Eui-Hyun Kim Jong Hee Chang Dong-Seok Kim Yong-Kil Hong Sun Ho Kim Su-Jae Lee Seok-Gu Kang Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients Stem Cells International |
| title | Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients |
| title_full | Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients |
| title_fullStr | Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients |
| title_full_unstemmed | Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients |
| title_short | Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients |
| title_sort | prognostic value of glioma cancer stem cell isolation in survival of primary glioblastoma patients |
| url | http://dx.doi.org/10.1155/2014/838950 |
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