Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review
Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small cell lung cancer (NSCLC) that is closely associated with Epstein-Barr virus (EBV) infection. While radiotherapy after induction chemotherapy have shown marked efficacy in nasopharyngeal carcinoma (NPC), its effectivene...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605900/full |
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| author | Gengda Huang Gengda Huang Hong He Hong He Yuting Fan Qinqin Ren Huixin Jiang Huixin Jiang Li Luo Li Guo Haiwen Chen Jiexia Zhang |
| author_facet | Gengda Huang Gengda Huang Hong He Hong He Yuting Fan Qinqin Ren Huixin Jiang Huixin Jiang Li Luo Li Guo Haiwen Chen Jiexia Zhang |
| author_sort | Gengda Huang |
| collection | DOAJ |
| description | Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small cell lung cancer (NSCLC) that is closely associated with Epstein-Barr virus (EBV) infection. While radiotherapy after induction chemotherapy have shown marked efficacy in nasopharyngeal carcinoma (NPC), its effectiveness in pLELC remains uncertain. A female with stage IIIB pLELC was treated with 4 cycles of gemcitabine plus cisplatin, achieving partial response(PR), followed by radical radiotherapy. Patients achieved clinical complete response(CR) with recurrence-free for over five years. This case highlights the potential of induction chemotherapy as an effective treatment for locally advanced pLELC. |
| format | Article |
| id | doaj-art-c8191c5d0e504f08b5c338d6ae426027 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c8191c5d0e504f08b5c338d6ae4260272025-08-20T03:58:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.16059001605900Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature reviewGengda Huang0Gengda Huang1Hong He2Hong He3Yuting Fan4Qinqin Ren5Huixin Jiang6Huixin Jiang7Li Luo8Li Guo9Haiwen Chen10Jiexia Zhang11Department of Respiratory and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, ChinaSchool of Clinical Medicine, Guangzhou Medical University, Guangzhou, Guangdong, ChinaDepartment of Respiratory and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, ChinaSchool of Clinical Medicine, Guangzhou Medical University, Guangzhou, Guangdong, ChinaSchool of Clinical Medicine, Guangzhou Medical University, Guangzhou, Guangdong, ChinaDepartment of Pulmonary and Critical Care Medicine of Jiangbei Campus, The First Affiliated Hospital of Army Medical University (The 958th Hospital of Chinese People's Liberation Army), Chongqing, ChinaDepartment of Respiratory and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, ChinaSchool of Clinical Medicine, Guangzhou Medical University, Guangzhou, Guangdong, ChinaSchool of Clinical Medicine, Guangzhou Medical University, Guangzhou, Guangdong, ChinaSchool of Clinical Medicine, Guangzhou Medical University, Guangzhou, Guangdong, ChinaDepartment of Respiratory and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, ChinaDepartment of Respiratory and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, ChinaPulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small cell lung cancer (NSCLC) that is closely associated with Epstein-Barr virus (EBV) infection. While radiotherapy after induction chemotherapy have shown marked efficacy in nasopharyngeal carcinoma (NPC), its effectiveness in pLELC remains uncertain. A female with stage IIIB pLELC was treated with 4 cycles of gemcitabine plus cisplatin, achieving partial response(PR), followed by radical radiotherapy. Patients achieved clinical complete response(CR) with recurrence-free for over five years. This case highlights the potential of induction chemotherapy as an effective treatment for locally advanced pLELC.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605900/fullnon-small cell lung cancerEpstein-Barr viruslymphoepithelioma-like carcinomainduction chemotherapyradical radiotherapy |
| spellingShingle | Gengda Huang Gengda Huang Hong He Hong He Yuting Fan Qinqin Ren Huixin Jiang Huixin Jiang Li Luo Li Guo Haiwen Chen Jiexia Zhang Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review Frontiers in Immunology non-small cell lung cancer Epstein-Barr virus lymphoepithelioma-like carcinoma induction chemotherapy radical radiotherapy |
| title | Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review |
| title_full | Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review |
| title_fullStr | Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review |
| title_full_unstemmed | Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review |
| title_short | Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review |
| title_sort | induction chemoradiotherapy achieves long term recurrence free survival in locally advanced pulmonary lymphoepithelioma like carcinoma a case report and literature review |
| topic | non-small cell lung cancer Epstein-Barr virus lymphoepithelioma-like carcinoma induction chemotherapy radical radiotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605900/full |
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