Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate
Objectives. To evaluate the distribution of neuroendocrine (NE) cells which may influence the development of benign prostatic hyperplasia (BPH) in the transition zone (TZ). Methods. We reviewed specimens from 80 patients who underwent radical prostatectomy in our institution and evaluated the densit...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2017/8541697 |
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| author | Yuki Kyoda Koji Ichihara Kohei Hashimoto Ko Kobayashi Fumimasa Fukuta Naoya Masumori |
| author_facet | Yuki Kyoda Koji Ichihara Kohei Hashimoto Ko Kobayashi Fumimasa Fukuta Naoya Masumori |
| author_sort | Yuki Kyoda |
| collection | DOAJ |
| description | Objectives. To evaluate the distribution of neuroendocrine (NE) cells which may influence the development of benign prostatic hyperplasia (BPH) in the transition zone (TZ). Methods. We reviewed specimens from 80 patients who underwent radical prostatectomy in our institution and evaluated the density of NE cells in the TZ. They were histologically classified into 3 groups: those with no adenomatous nodule in the TZ (group A), those with small nodules with normal epithelium and stroma around them in the TZ (group B), and those with large nodules occupying the TZ (group C). In the patients of group B, intra-adenoma (adenomatous nodules) and extra-adenoma (normal tissue) NE cells in the TZ were separately counted. Results. There were 22, 23, and 35 patients in groups A, B, and C, respectively. The median density of NE cells in the TZ of group B patients, 2.80/mm2, was significantly higher than that of NE cells in group A, 1.43/mm2, and group C, 0.61/mm2 (p<0.001). In group B, the median density of extra-adenoma NE cells was significantly higher than that of intra-adenoma. Conclusions. Many NE cells exist around small adenoma in the TZ. NE cells may influence the initial growth of BPH in a paracrine fashion. Trial Registration. This study approved by our institutional review board was retrospectively registered (#272-14). |
| format | Article |
| id | doaj-art-c8186cff15b749af937044ea063e935e |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-c8186cff15b749af937044ea063e935e2025-02-03T01:11:43ZengWileyAdvances in Urology1687-63691687-63772017-01-01201710.1155/2017/85416978541697Distribution of Neuroendocrine Cells in the Transition Zone of the ProstateYuki Kyoda0Koji Ichihara1Kohei Hashimoto2Ko Kobayashi3Fumimasa Fukuta4Naoya Masumori5Department of Urology, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Urology, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Urology, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Urology, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Urology, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Urology, Sapporo Medical University School of Medicine, Sapporo, JapanObjectives. To evaluate the distribution of neuroendocrine (NE) cells which may influence the development of benign prostatic hyperplasia (BPH) in the transition zone (TZ). Methods. We reviewed specimens from 80 patients who underwent radical prostatectomy in our institution and evaluated the density of NE cells in the TZ. They were histologically classified into 3 groups: those with no adenomatous nodule in the TZ (group A), those with small nodules with normal epithelium and stroma around them in the TZ (group B), and those with large nodules occupying the TZ (group C). In the patients of group B, intra-adenoma (adenomatous nodules) and extra-adenoma (normal tissue) NE cells in the TZ were separately counted. Results. There were 22, 23, and 35 patients in groups A, B, and C, respectively. The median density of NE cells in the TZ of group B patients, 2.80/mm2, was significantly higher than that of NE cells in group A, 1.43/mm2, and group C, 0.61/mm2 (p<0.001). In group B, the median density of extra-adenoma NE cells was significantly higher than that of intra-adenoma. Conclusions. Many NE cells exist around small adenoma in the TZ. NE cells may influence the initial growth of BPH in a paracrine fashion. Trial Registration. This study approved by our institutional review board was retrospectively registered (#272-14).http://dx.doi.org/10.1155/2017/8541697 |
| spellingShingle | Yuki Kyoda Koji Ichihara Kohei Hashimoto Ko Kobayashi Fumimasa Fukuta Naoya Masumori Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate Advances in Urology |
| title | Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate |
| title_full | Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate |
| title_fullStr | Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate |
| title_full_unstemmed | Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate |
| title_short | Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate |
| title_sort | distribution of neuroendocrine cells in the transition zone of the prostate |
| url | http://dx.doi.org/10.1155/2017/8541697 |
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