Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization
Abstract Osteomyelitis, characterized by bone inflammation and infection, poses a significant global health burden. This Mendelian randomization (MR) study investigates the causal relationship between polyunsaturated fatty acids (PUFAs) and osteomyelitis risk. By using GWAS data from 114,999 individ...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-98502-1 |
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| author | Baixing Chen Bin Pu Shi Lin Shaoshuo Li Hang Dong |
| author_facet | Baixing Chen Bin Pu Shi Lin Shaoshuo Li Hang Dong |
| author_sort | Baixing Chen |
| collection | DOAJ |
| description | Abstract Osteomyelitis, characterized by bone inflammation and infection, poses a significant global health burden. This Mendelian randomization (MR) study investigates the causal relationship between polyunsaturated fatty acids (PUFAs) and osteomyelitis risk. By using GWAS data from 114,999 individuals, we explore specific PUFAs and their genetic variations using Inverse variance weighted (IVW), MR-Egger and weighted median methods. The results reveal a suggestive association between genetically predicted higher docosahexaenoic acid (DHA) and omega-6 levels with increased osteomyelitis risk. Conversely, a negative association is found for the omega-6:3 ratio. Linoleic acid, omega-3, and omega-6 show no significant associations. Heterogeneity and pleiotropy analyses support result robustness, indicating minimal confounding effects. Sensitivity analyses confirm the stability of findings. Our MR analysis challenges the presumed protective role of omega-3 in osteomyelitis, suggesting a nuanced relationship where DHA may pose an increased risk. The study underscores the complexity of fatty acid interactions influenced by genetic variability and dietary nuances. Further research is essential to unravel underlying mechanisms and translate these findings into actionable strategies for osteomyelitis prevention and treatment. |
| format | Article |
| id | doaj-art-c816c5cb58d54bda98ec44486887c65a |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-c816c5cb58d54bda98ec44486887c65a2025-08-20T02:11:10ZengNature PortfolioScientific Reports2045-23222025-04-011511810.1038/s41598-025-98502-1Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomizationBaixing Chen0Bin Pu1Shi Lin2Shaoshuo Li3Hang Dong4Department of Development and Regeneration, KU LeuvenDepartment of Orthopedics, Suining Traditional Chinese Medicine Hospital Affiliated to North Sichuan Medical CollegeShenzhen Pingle Orthopedic HospitalWuxi Affiliated Hospital of Nanjing University of Traditional Chinese MedicineThe First Affiliated Hospital, Guangzhou University of Chinese MedicineAbstract Osteomyelitis, characterized by bone inflammation and infection, poses a significant global health burden. This Mendelian randomization (MR) study investigates the causal relationship between polyunsaturated fatty acids (PUFAs) and osteomyelitis risk. By using GWAS data from 114,999 individuals, we explore specific PUFAs and their genetic variations using Inverse variance weighted (IVW), MR-Egger and weighted median methods. The results reveal a suggestive association between genetically predicted higher docosahexaenoic acid (DHA) and omega-6 levels with increased osteomyelitis risk. Conversely, a negative association is found for the omega-6:3 ratio. Linoleic acid, omega-3, and omega-6 show no significant associations. Heterogeneity and pleiotropy analyses support result robustness, indicating minimal confounding effects. Sensitivity analyses confirm the stability of findings. Our MR analysis challenges the presumed protective role of omega-3 in osteomyelitis, suggesting a nuanced relationship where DHA may pose an increased risk. The study underscores the complexity of fatty acid interactions influenced by genetic variability and dietary nuances. Further research is essential to unravel underlying mechanisms and translate these findings into actionable strategies for osteomyelitis prevention and treatment.https://doi.org/10.1038/s41598-025-98502-1 |
| spellingShingle | Baixing Chen Bin Pu Shi Lin Shaoshuo Li Hang Dong Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization Scientific Reports |
| title | Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization |
| title_full | Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization |
| title_fullStr | Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization |
| title_full_unstemmed | Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization |
| title_short | Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization |
| title_sort | investigating the association between polyunsaturated fatty acids and osteomyelitis by mendelian randomization |
| url | https://doi.org/10.1038/s41598-025-98502-1 |
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