How leaky is the gut in Parkinson’s disease?
Summary: The intestinal epithelial barrier (IEB) plays a critical role in health and disease by regulating the absorption of nutrients, electrolytes and water while preventing gut translocation of pathogens. A compromised intestinal barrier has been reported in Parkinson’s disease (PD) further reinf...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396425002403 |
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| author | Pascal Derkinderen François Cossais Kristína Kulcsárová Matej Škorvánek Loïc Sellier-Montaigne Emmanuel Coron Laurène Leclair-Visonneau Silvia Cerri Carolina Pellegrini Malvyne Rolli-Derkinderen |
| author_facet | Pascal Derkinderen François Cossais Kristína Kulcsárová Matej Škorvánek Loïc Sellier-Montaigne Emmanuel Coron Laurène Leclair-Visonneau Silvia Cerri Carolina Pellegrini Malvyne Rolli-Derkinderen |
| author_sort | Pascal Derkinderen |
| collection | DOAJ |
| description | Summary: The intestinal epithelial barrier (IEB) plays a critical role in health and disease by regulating the absorption of nutrients, electrolytes and water while preventing gut translocation of pathogens. A compromised intestinal barrier has been reported in Parkinson’s disease (PD) further reinforcing the assumption that PD is a gut-brain axis disorder and suggesting that gut-derived factors may participate in disease development and/or progression. However, the diversity of methodology between existing studies on gut permeability in PD, especially regarding the methods used for the evaluation of the IEB, has led to diverging results and it is definitely too early to draw any definite conclusions. We envision novel approaches, such as intestinal organoids and confocal laser endomicroscopy that could be used to study more precisely the IEB in PD. |
| format | Article |
| id | doaj-art-c814bd0be4af4ce2a56a1dc2682ed4b9 |
| institution | OA Journals |
| issn | 2352-3964 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj-art-c814bd0be4af4ce2a56a1dc2682ed4b92025-08-20T02:03:19ZengElsevierEBioMedicine2352-39642025-07-0111710579610.1016/j.ebiom.2025.105796How leaky is the gut in Parkinson’s disease?Pascal Derkinderen0François Cossais1Kristína Kulcsárová2Matej Škorvánek3Loïc Sellier-Montaigne4Emmanuel Coron5Laurène Leclair-Visonneau6Silvia Cerri7Carolina Pellegrini8Malvyne Rolli-Derkinderen9Nantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, France; Corresponding author. Inserm U1235 Nantes, 1 rue Gaston Veil, Nantes 44035, France.Department of Anatomy, Kiel University, GermanyDepartment of Neurology, P. J. Safarik University, Kosice, Slovak Republic; Department of Neurology, L. Pasteur University Hospital, Kosice, Slovak Republic; Department of Clinical Neurosciences, University Scientific Park MEDIPARK, P. J. Safarik University, Kosice, Slovak RepublicDepartment of Neurology, P. J. Safarik University, Kosice, Slovak Republic; Department of Neurology, L. Pasteur University Hospital, Kosice, Slovak Republic; Department of Clinical Neurosciences, University Scientific Park MEDIPARK, P. J. Safarik University, Kosice, Slovak RepublicNantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, FranceNantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, FranceNantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, FranceUnit of Cellular and Molecular Neurobiology, IRCCS Mondino Foundation, Pavia 27100, ItalyUnit of Histology and Embryology, Department of Clinical and Experimental Medicine, University of Pisa, ItalyNantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, FranceSummary: The intestinal epithelial barrier (IEB) plays a critical role in health and disease by regulating the absorption of nutrients, electrolytes and water while preventing gut translocation of pathogens. A compromised intestinal barrier has been reported in Parkinson’s disease (PD) further reinforcing the assumption that PD is a gut-brain axis disorder and suggesting that gut-derived factors may participate in disease development and/or progression. However, the diversity of methodology between existing studies on gut permeability in PD, especially regarding the methods used for the evaluation of the IEB, has led to diverging results and it is definitely too early to draw any definite conclusions. We envision novel approaches, such as intestinal organoids and confocal laser endomicroscopy that could be used to study more precisely the IEB in PD.http://www.sciencedirect.com/science/article/pii/S2352396425002403Parkinson’s diseaseIntestinal epithelial barrierIntestinal permeabilityTight junctionsUssing chamberOrganoids |
| spellingShingle | Pascal Derkinderen François Cossais Kristína Kulcsárová Matej Škorvánek Loïc Sellier-Montaigne Emmanuel Coron Laurène Leclair-Visonneau Silvia Cerri Carolina Pellegrini Malvyne Rolli-Derkinderen How leaky is the gut in Parkinson’s disease? EBioMedicine Parkinson’s disease Intestinal epithelial barrier Intestinal permeability Tight junctions Ussing chamber Organoids |
| title | How leaky is the gut in Parkinson’s disease? |
| title_full | How leaky is the gut in Parkinson’s disease? |
| title_fullStr | How leaky is the gut in Parkinson’s disease? |
| title_full_unstemmed | How leaky is the gut in Parkinson’s disease? |
| title_short | How leaky is the gut in Parkinson’s disease? |
| title_sort | how leaky is the gut in parkinson s disease |
| topic | Parkinson’s disease Intestinal epithelial barrier Intestinal permeability Tight junctions Ussing chamber Organoids |
| url | http://www.sciencedirect.com/science/article/pii/S2352396425002403 |
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