New perspectives on autism: two equations to describe a complex disorder and envisage new treatments

Autism spectrum disorder (ASD) is a neurodevelopmental condition that can be reliably diagnosed in children by age 18–24 months. Prospective longitudinal studies of infants aged 1 year and younger who are later diagnosed with autism are elucidating the early developmental course of autism and identi...

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Main Authors: B. Suare, M.-A. Jeune
Format: Article
Language:Russian
Published: IRBIS LLC 2025-01-01
Series:Акушерство, гинекология и репродукция
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Online Access:https://www.gynecology.su/jour/article/view/2290
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author B. Suare
M.-A. Jeune
author_facet B. Suare
M.-A. Jeune
author_sort B. Suare
collection DOAJ
description Autism spectrum disorder (ASD) is a neurodevelopmental condition that can be reliably diagnosed in children by age 18–24 months. Prospective longitudinal studies of infants aged 1 year and younger who are later diagnosed with autism are elucidating the early developmental course of autism and identifying ways of predicting autism before diagnosis is possible. Studies that use magnetic resonance imaging and electroencephalography, have identified differences in brain development in infants later diagnosed with autism compared with infants without autism. Retrospective studies of infants younger than 1 year who received a later diagnosis of autism have also showed an increased prevalence of health conditions, such as sleep disorders, gastrointestinal disorders, and vision problems. We propose two equations to describe this complex disorder: the first indicates the factors at the origin of the disease, the second synthesizes the different factors leading to a more or less severe disease. Although research findings offer insight on promising screening approaches for predicting autism in infants, individual-level predictions remain a future goal. Multiple scientific challenges and ethical questions remain to be addressed to translate research on early brain-based and behavioural predictors of autism into feasible and reliable screening tools for clinical practice.
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spelling doaj-art-c814a378bd5d4e0cb391e1be90e0b7bd2025-08-20T03:57:39ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942025-01-0118688289010.17749/2313-7347/ob.gyn.rep.2024.526939New perspectives on autism: two equations to describe a complex disorder and envisage new treatmentsB. Suare0M.-A. Jeune1Radiology Department, Hopital de Garches, Universite Paris-SaclayLes Papillons Blancs de la Colline, Centre de Recherche et d'Excellence sur l'autisme, Hopital de jour Les LierresAutism spectrum disorder (ASD) is a neurodevelopmental condition that can be reliably diagnosed in children by age 18–24 months. Prospective longitudinal studies of infants aged 1 year and younger who are later diagnosed with autism are elucidating the early developmental course of autism and identifying ways of predicting autism before diagnosis is possible. Studies that use magnetic resonance imaging and electroencephalography, have identified differences in brain development in infants later diagnosed with autism compared with infants without autism. Retrospective studies of infants younger than 1 year who received a later diagnosis of autism have also showed an increased prevalence of health conditions, such as sleep disorders, gastrointestinal disorders, and vision problems. We propose two equations to describe this complex disorder: the first indicates the factors at the origin of the disease, the second synthesizes the different factors leading to a more or less severe disease. Although research findings offer insight on promising screening approaches for predicting autism in infants, individual-level predictions remain a future goal. Multiple scientific challenges and ethical questions remain to be addressed to translate research on early brain-based and behavioural predictors of autism into feasible and reliable screening tools for clinical practice.https://www.gynecology.su/jour/article/view/2290autism spectrum disorderasdearly diagnosisneuroplasticity
spellingShingle B. Suare
M.-A. Jeune
New perspectives on autism: two equations to describe a complex disorder and envisage new treatments
Акушерство, гинекология и репродукция
autism spectrum disorder
asd
early diagnosis
neuroplasticity
title New perspectives on autism: two equations to describe a complex disorder and envisage new treatments
title_full New perspectives on autism: two equations to describe a complex disorder and envisage new treatments
title_fullStr New perspectives on autism: two equations to describe a complex disorder and envisage new treatments
title_full_unstemmed New perspectives on autism: two equations to describe a complex disorder and envisage new treatments
title_short New perspectives on autism: two equations to describe a complex disorder and envisage new treatments
title_sort new perspectives on autism two equations to describe a complex disorder and envisage new treatments
topic autism spectrum disorder
asd
early diagnosis
neuroplasticity
url https://www.gynecology.su/jour/article/view/2290
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