The human host response to monkeypox infection: a proteomic case series study
Abstract The rapid rise of monkeypox (MPX) cases outside previously endemic areas prompts for a better understanding of the disease. We studied the plasma proteome of a group of MPX patients with a similar infection history and clinical manifestation typical for the current outbreak. We report that...
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| Format: | Article |
| Language: | English |
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Springer Nature
2022-09-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202216643 |
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| author | Ziyue Wang Pinkus Tober‐Lau Vadim Farztdinov Oliver Lemke Torsten Schwecke Sarah Steinbrecher Julia Muenzner Helene Kriedemann Leif Erik Sander Johannes Hartl Michael Mülleder Markus Ralser Florian Kurth |
| author_facet | Ziyue Wang Pinkus Tober‐Lau Vadim Farztdinov Oliver Lemke Torsten Schwecke Sarah Steinbrecher Julia Muenzner Helene Kriedemann Leif Erik Sander Johannes Hartl Michael Mülleder Markus Ralser Florian Kurth |
| author_sort | Ziyue Wang |
| collection | DOAJ |
| description | Abstract The rapid rise of monkeypox (MPX) cases outside previously endemic areas prompts for a better understanding of the disease. We studied the plasma proteome of a group of MPX patients with a similar infection history and clinical manifestation typical for the current outbreak. We report that MPX in this case series is associated with a strong plasma proteomic response among nutritional and acute phase response proteins. Moreover, we report a correlation between plasma proteins and disease severity. Contrasting the MPX host response with that of COVID‐19, we find a range of similarities, but also important differences. For instance, CFHR1 is induced in COVID‐19, but suppressed in MPX, reflecting the different roles of the complement system in the two infectious diseases. Of note, the spatial overlap in response proteins suggested that a COVID‐19 biomarker panel assay could be repurposed for MPX. Applying a targeted protein panel assay provided encouraging results and distinguished MPX cases from healthy controls. Hence, our results provide a first proteomic characterization of the MPX human host response and encourage further research on protein‐panel assays in emerging infectious diseases. |
| format | Article |
| id | doaj-art-c8124d021574465f89bd6a63f7db6a43 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-c8124d021574465f89bd6a63f7db6a432025-08-20T04:03:07ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842022-09-01141111110.15252/emmm.202216643The human host response to monkeypox infection: a proteomic case series studyZiyue Wang0Pinkus Tober‐Lau1Vadim Farztdinov2Oliver Lemke3Torsten Schwecke4Sarah Steinbrecher5Julia Muenzner6Helene Kriedemann7Leif Erik Sander8Johannes Hartl9Michael Mülleder10Markus Ralser11Florian Kurth12Department of Biochemistry, Charité – Universitätsmedizin BerlinDepartment of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin BerlinCore Facility High Throughput Mass Spectrometry, Charité – Universitätsmedizin BerlinDepartment of Biochemistry, Charité – Universitätsmedizin BerlinDepartment of Biochemistry, Charité – Universitätsmedizin BerlinDepartment of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin BerlinDepartment of Biochemistry, Charité – Universitätsmedizin BerlinDepartment of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin BerlinDepartment of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin BerlinDepartment of Biochemistry, Charité – Universitätsmedizin BerlinCore Facility High Throughput Mass Spectrometry, Charité – Universitätsmedizin BerlinDepartment of Biochemistry, Charité – Universitätsmedizin BerlinDepartment of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin BerlinAbstract The rapid rise of monkeypox (MPX) cases outside previously endemic areas prompts for a better understanding of the disease. We studied the plasma proteome of a group of MPX patients with a similar infection history and clinical manifestation typical for the current outbreak. We report that MPX in this case series is associated with a strong plasma proteomic response among nutritional and acute phase response proteins. Moreover, we report a correlation between plasma proteins and disease severity. Contrasting the MPX host response with that of COVID‐19, we find a range of similarities, but also important differences. For instance, CFHR1 is induced in COVID‐19, but suppressed in MPX, reflecting the different roles of the complement system in the two infectious diseases. Of note, the spatial overlap in response proteins suggested that a COVID‐19 biomarker panel assay could be repurposed for MPX. Applying a targeted protein panel assay provided encouraging results and distinguished MPX cases from healthy controls. Hence, our results provide a first proteomic characterization of the MPX human host response and encourage further research on protein‐panel assays in emerging infectious diseases.https://doi.org/10.15252/emmm.202216643host responsemonkeypox virusproteomicsviral infection |
| spellingShingle | Ziyue Wang Pinkus Tober‐Lau Vadim Farztdinov Oliver Lemke Torsten Schwecke Sarah Steinbrecher Julia Muenzner Helene Kriedemann Leif Erik Sander Johannes Hartl Michael Mülleder Markus Ralser Florian Kurth The human host response to monkeypox infection: a proteomic case series study EMBO Molecular Medicine host response monkeypox virus proteomics viral infection |
| title | The human host response to monkeypox infection: a proteomic case series study |
| title_full | The human host response to monkeypox infection: a proteomic case series study |
| title_fullStr | The human host response to monkeypox infection: a proteomic case series study |
| title_full_unstemmed | The human host response to monkeypox infection: a proteomic case series study |
| title_short | The human host response to monkeypox infection: a proteomic case series study |
| title_sort | human host response to monkeypox infection a proteomic case series study |
| topic | host response monkeypox virus proteomics viral infection |
| url | https://doi.org/10.15252/emmm.202216643 |
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