Intrinsic pathway activation in patients with antiphospholipid syndrome and healthy controls

Intrinsic pathway activation in patients with antiphospholipid syndrome and healthy controls

Background: Antiphospholipid syndrome (APS) is a thrombotic autoimmune disease. Activation of the intrinsic coagulation pathway contributes to inflammatory and cardiovascular diseases, but its role in APS is unknown. Increased release of neutrophil extracellular traps and reduced effectiveness of di...

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Main Authors: Dagmar J.M. van Mourik, Valérie L.B.I. Jansen, Michiel Coppens, Saskia Middeldorp, Hugo ten Cate, Harry R. Büller, Henri M.H. Spronk, Magdolna Nagy, Thijs E. van Mens
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
antiphospholipid syndrome
coagulation cascade
factor XII
intrinsic pathway
thrombotic autoimmune disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2475037925000184
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