Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian Practices
Background: Kidney failure is a prevalent condition with tendency for familial clustering in up to 27% of the affected individuals. Living kidney donor (LKD) transplantation is the optimal treatment option; however, in Canada, more than 45% of LKDs are biologically related to their recipients which...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Canadian Journal of Kidney Health and Disease |
| Online Access: | https://doi.org/10.1177/20543581241293200 |
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| author | Somaya Zahran Ke Fan Bei Aisha Adil Princess Okoh Thomas Kitzler Ahsan Alam |
| author_facet | Somaya Zahran Ke Fan Bei Aisha Adil Princess Okoh Thomas Kitzler Ahsan Alam |
| author_sort | Somaya Zahran |
| collection | DOAJ |
| description | Background: Kidney failure is a prevalent condition with tendency for familial clustering in up to 27% of the affected individuals. Living kidney donor (LKD) transplantation is the optimal treatment option; however, in Canada, more than 45% of LKDs are biologically related to their recipients which subjects recipients to worse graft survival and donors to higher future risk of kidney failure. Although not fully understood, this observation could be partially explained by genetic predisposition to kidney diseases. Genetic testing of potential LKDs may improve risk assessment and inform the safety of donation. The strategies to evaluate these donors are still evolving. In Canada, little is known about the practice of assessing for genetic conditions among LKDs. Aim: The aim was to examine the Canadian practices regarding LKDs genetic assessment. Methods: Questionnaires were sent to 23 Canadian adult transplant centers to examine their protocols for LKDs genetic assessment. Design: The questionnaire comprised of 10 sections and 21 questions including case scenarios of different LKD encounters. Major domains of the survey addressed general demographics, information sharing practices, effect of mode of inheritance on candidacy decision, having a policy for LKD genetic evaluation, and case scenarios covering the following conditions: autosomal dominant polycystic kidney disease (ADPKD), Alport syndrome, Fabry disease, familial focal and segmental glomerulosclerosis (FSGS), atypical hemolytic uremic syndrome (aHUS), autosomal dominant tubulointerstitial kidney disease (ADTKD), sickle cell, and apolipoprotein L1 mutation (APOL1). Participants: The questionnaire was sent to the living-donor assessment committee representative (nephrologist) in adult and pediatric kidney transplant centers across Canada. Results: In total, 16 of 23 Canadian centers responded to the survey. Of the 8 surveyed genetic conditions, ADPKD, Alport syndrome, and aHUS were the most frequently encountered. More centers have specific policies for donor evaluation for ADPKD (25%) and aHUS (21.4%) vs none to very few for other genetic conditions. The most cited guidelines are Kidney Disease Improving Global Outcomes (KDIGO), Canadian Society of Nephrology/Canadian Society of Transplantation (CSN/CST), and the Canadian Blood Services’ Kidney Paired Donation Protocol. Conclusions: Canadian transplant centers follow a case-by-case approach rather than a standard protocol for genetic assessment of LKDs given that current guideline recommendations are based on expert opinion due to a lack of a reliable body of evidence. With the expected rise in utilization of the increasingly available genetic testing, early multidisciplinary assessment including medical geneticists has the potential to improve personalized management. Studies examining long-term donor and graft outcomes are needed to construct the basis for evidence-based recommendations and inform the safety of donations. |
| format | Article |
| id | doaj-art-c80c8ce4511842a890348a11d2816f8e |
| institution | Kabale University |
| issn | 2054-3581 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Canadian Journal of Kidney Health and Disease |
| spelling | doaj-art-c80c8ce4511842a890348a11d2816f8e2025-01-10T14:03:29ZengSAGE PublishingCanadian Journal of Kidney Health and Disease2054-35812025-01-011210.1177/20543581241293200Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian PracticesSomaya Zahran0Ke Fan Bei1Aisha Adil2Princess Okoh3Thomas Kitzler4Ahsan Alam5Division of Nephrology, Department of Medicine, McGill University Health Center, Montreal, QC, CanadaLatner Thoracic Surgery Research Laboratories, Toronto General Hospital, The University Health Network, ON, CanadaCanadian Donation and Transplantation Research Program, Edmonton, AB, CanadaAjmera Transplant Center, Toronto General Hospital, The University Health Network, ON, CanadaChild Health and Human Development Program, Research Institute of MUHC, McGill University Health Centre, Montreal, QC, CanadaMultiorgan Transplant Program, Division of Nephrology, Department of Medicine, McGill University Health Centre, Montreal, QC, CanadaBackground: Kidney failure is a prevalent condition with tendency for familial clustering in up to 27% of the affected individuals. Living kidney donor (LKD) transplantation is the optimal treatment option; however, in Canada, more than 45% of LKDs are biologically related to their recipients which subjects recipients to worse graft survival and donors to higher future risk of kidney failure. Although not fully understood, this observation could be partially explained by genetic predisposition to kidney diseases. Genetic testing of potential LKDs may improve risk assessment and inform the safety of donation. The strategies to evaluate these donors are still evolving. In Canada, little is known about the practice of assessing for genetic conditions among LKDs. Aim: The aim was to examine the Canadian practices regarding LKDs genetic assessment. Methods: Questionnaires were sent to 23 Canadian adult transplant centers to examine their protocols for LKDs genetic assessment. Design: The questionnaire comprised of 10 sections and 21 questions including case scenarios of different LKD encounters. Major domains of the survey addressed general demographics, information sharing practices, effect of mode of inheritance on candidacy decision, having a policy for LKD genetic evaluation, and case scenarios covering the following conditions: autosomal dominant polycystic kidney disease (ADPKD), Alport syndrome, Fabry disease, familial focal and segmental glomerulosclerosis (FSGS), atypical hemolytic uremic syndrome (aHUS), autosomal dominant tubulointerstitial kidney disease (ADTKD), sickle cell, and apolipoprotein L1 mutation (APOL1). Participants: The questionnaire was sent to the living-donor assessment committee representative (nephrologist) in adult and pediatric kidney transplant centers across Canada. Results: In total, 16 of 23 Canadian centers responded to the survey. Of the 8 surveyed genetic conditions, ADPKD, Alport syndrome, and aHUS were the most frequently encountered. More centers have specific policies for donor evaluation for ADPKD (25%) and aHUS (21.4%) vs none to very few for other genetic conditions. The most cited guidelines are Kidney Disease Improving Global Outcomes (KDIGO), Canadian Society of Nephrology/Canadian Society of Transplantation (CSN/CST), and the Canadian Blood Services’ Kidney Paired Donation Protocol. Conclusions: Canadian transplant centers follow a case-by-case approach rather than a standard protocol for genetic assessment of LKDs given that current guideline recommendations are based on expert opinion due to a lack of a reliable body of evidence. With the expected rise in utilization of the increasingly available genetic testing, early multidisciplinary assessment including medical geneticists has the potential to improve personalized management. Studies examining long-term donor and graft outcomes are needed to construct the basis for evidence-based recommendations and inform the safety of donations.https://doi.org/10.1177/20543581241293200 |
| spellingShingle | Somaya Zahran Ke Fan Bei Aisha Adil Princess Okoh Thomas Kitzler Ahsan Alam Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian Practices Canadian Journal of Kidney Health and Disease |
| title | Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian Practices |
| title_full | Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian Practices |
| title_fullStr | Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian Practices |
| title_full_unstemmed | Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian Practices |
| title_short | Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian Practices |
| title_sort | genetic assessment of living kidney transplant donors a survey of canadian practices |
| url | https://doi.org/10.1177/20543581241293200 |
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