Relación entre la enzima convertidora de angiotensina, polimorfismo I/D, y obstrucción coronaria en una población del Quindío, Colombia
Relationship between angiotensin-converting enzyme, I/D polymorphism, and coronary obstruction in a population of Quindío,Colombia. Angiotensin-converting enzyme (ACE) activity in serum and insertion/deletion (I/D) polymorphism have been associated tocardiovascular disease in several studies. Object...
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Pontificia Universidad Javeriana
2011-12-01
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| Series: | Universitas Scientiarum |
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| Online Access: | http://revistas.javeriana.edu.co/index.php/scientarium/article/view/1792/1152 |
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| author | Patricia Landázuri Hugo Castaño Nelsy Loango Andrea Cardona-Barreto Alejandra María Giraldo |
| author_facet | Patricia Landázuri Hugo Castaño Nelsy Loango Andrea Cardona-Barreto Alejandra María Giraldo |
| author_sort | Patricia Landázuri |
| collection | DOAJ |
| description | Relationship between angiotensin-converting enzyme, I/D polymorphism, and coronary obstruction in a population of Quindío,Colombia. Angiotensin-converting enzyme (ACE) activity in serum and insertion/deletion (I/D) polymorphism have been associated tocardiovascular disease in several studies. Objective. To find a relationship between ACE activity and I/D polymorphism in the enzymegene in patients with coronary obstruction revealed by angiography. Materials and methods. Sample comprised patients attending ahemodynamics center in Quindío in need of a coronary angiography. ACE activity was measured by spectrophotometry and the I/Dgenotype determined by polymerase chain reaction. Results. 542 patients were divided into two groups: individuals with coronaryobstruction higher than or equal to 50% (OC≥50) and individuals with coronary obstruction less than 50% (CO<50%). Serum ACEactivity in the global population was higher in individuals with DD polymorphism, followed by ID and II with significant differences.A similar pattern was shown in both study groups but without significant differences, although enzyme activity was always higher inindividuals with OC≥50% compared with patients with OC<50%. ID genotype was the most frequent in both groups. No differenceswere found in allele and genotype frequencies in the study groups. Conclusions. Significant differences in ACE activity were foundaccording to genotype. Our study did not find any relationship between ACE activity, I/D polymorphisms and coronary obstruction. |
| format | Article |
| id | doaj-art-c809d8d1ccc546de937ecc7f467659ee |
| institution | OA Journals |
| issn | 0122-7483 2027-1352 |
| language | English |
| publishDate | 2011-12-01 |
| publisher | Pontificia Universidad Javeriana |
| record_format | Article |
| series | Universitas Scientiarum |
| spelling | doaj-art-c809d8d1ccc546de937ecc7f467659ee2025-08-20T02:20:06ZengPontificia Universidad JaverianaUniversitas Scientiarum0122-74832027-13522011-12-01163193199Relación entre la enzima convertidora de angiotensina, polimorfismo I/D, y obstrucción coronaria en una población del Quindío, ColombiaPatricia LandázuriHugo CastañoNelsy LoangoAndrea Cardona-BarretoAlejandra María GiraldoRelationship between angiotensin-converting enzyme, I/D polymorphism, and coronary obstruction in a population of Quindío,Colombia. Angiotensin-converting enzyme (ACE) activity in serum and insertion/deletion (I/D) polymorphism have been associated tocardiovascular disease in several studies. Objective. To find a relationship between ACE activity and I/D polymorphism in the enzymegene in patients with coronary obstruction revealed by angiography. Materials and methods. Sample comprised patients attending ahemodynamics center in Quindío in need of a coronary angiography. ACE activity was measured by spectrophotometry and the I/Dgenotype determined by polymerase chain reaction. Results. 542 patients were divided into two groups: individuals with coronaryobstruction higher than or equal to 50% (OC≥50) and individuals with coronary obstruction less than 50% (CO<50%). Serum ACEactivity in the global population was higher in individuals with DD polymorphism, followed by ID and II with significant differences.A similar pattern was shown in both study groups but without significant differences, although enzyme activity was always higher inindividuals with OC≥50% compared with patients with OC<50%. ID genotype was the most frequent in both groups. No differenceswere found in allele and genotype frequencies in the study groups. Conclusions. Significant differences in ACE activity were foundaccording to genotype. Our study did not find any relationship between ACE activity, I/D polymorphisms and coronary obstruction.http://revistas.javeriana.edu.co/index.php/scientarium/article/view/1792/1152angiotensin-converting enzymecoronary obstructionID polymorphismangiotensin. |
| spellingShingle | Patricia Landázuri Hugo Castaño Nelsy Loango Andrea Cardona-Barreto Alejandra María Giraldo Relación entre la enzima convertidora de angiotensina, polimorfismo I/D, y obstrucción coronaria en una población del Quindío, Colombia Universitas Scientiarum angiotensin-converting enzyme coronary obstruction ID polymorphism angiotensin. |
| title | Relación entre la enzima convertidora de angiotensina, polimorfismo I/D, y obstrucción coronaria en una población del Quindío, Colombia |
| title_full | Relación entre la enzima convertidora de angiotensina, polimorfismo I/D, y obstrucción coronaria en una población del Quindío, Colombia |
| title_fullStr | Relación entre la enzima convertidora de angiotensina, polimorfismo I/D, y obstrucción coronaria en una población del Quindío, Colombia |
| title_full_unstemmed | Relación entre la enzima convertidora de angiotensina, polimorfismo I/D, y obstrucción coronaria en una población del Quindío, Colombia |
| title_short | Relación entre la enzima convertidora de angiotensina, polimorfismo I/D, y obstrucción coronaria en una población del Quindío, Colombia |
| title_sort | relacion entre la enzima convertidora de angiotensina polimorfismo i d y obstruccion coronaria en una poblacion del quindio colombia |
| topic | angiotensin-converting enzyme coronary obstruction ID polymorphism angiotensin. |
| url | http://revistas.javeriana.edu.co/index.php/scientarium/article/view/1792/1152 |
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