Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular disease associated with metabolic comorbidities. Microvascular dysfunction has been proposed to drive HFpEF, likely via endothelial cell (EC) dysfunction, yet the role of the mural cells herein has...

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Bibliographic Details
Main Authors: Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cardiovascular Diabetology
Subjects:
Pericytes
Smooth muscle cells
Endothelial cells
HFpEF
Diastolic dysfunction
Online Access:https://doi.org/10.1186/s12933-025-02623-w
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