A case of Hemophagocytic Lymphohistiocytosis presenting as Pyrexia of Unknown Origin
Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyper inflammatory condition which occurs as either primary (genetic) or secondary (acquired) due to impaired or absent function of Natural Killer cells and cytotoxic cells. Common secondary causes include viral and bacterial infections...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1928 |
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| author | Indira M Meera Nair Prabhalaksmi K K Andrews M A |
| author_facet | Indira M Meera Nair Prabhalaksmi K K Andrews M A |
| author_sort | Indira M |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyper inflammatory condition which occurs as either primary (genetic) or secondary (acquired) due to impaired or absent function of Natural Killer cells and cytotoxic cells. Common secondary causes include viral and bacterial infections, autoimmune diseases and hematological malignancies. Extensive phagocytosis of blood cells by histiocytes in bone marrow, spleen, liver and lymphnodes result in peripheral blood cytopenias, hepatosplenomegaly and lymphadenopathy. We evaluated a case of pyrexia of unknown origin and found out that he fulfilled the criteria for diagnosing hemophagocytic lymphohistiocytosis. He was started on immunochemotherapy with etoposide, cyclosporine and steroids, but he succumbed to illness within two weeks of treatment. High index of suspicion is needed to diagnose HLH and prompt treatment on diagnosis can be life saving |
| format | Article |
| id | doaj-art-c80853e9ea5e4f49b4cd1b65ec404b30 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-c80853e9ea5e4f49b4cd1b65ec404b302025-08-20T01:47:48ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011A case of Hemophagocytic Lymphohistiocytosis presenting as Pyrexia of Unknown OriginIndira M0Meera Nair1Prabhalaksmi K K2Andrews M A3GMC, Thrissur, Kerala, IndiaGMC, Thrissur, Kerala, IndiaGMC, Thrissur, Kerala, IndiaGMC, Thrissur, Kerala, IndiaHemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyper inflammatory condition which occurs as either primary (genetic) or secondary (acquired) due to impaired or absent function of Natural Killer cells and cytotoxic cells. Common secondary causes include viral and bacterial infections, autoimmune diseases and hematological malignancies. Extensive phagocytosis of blood cells by histiocytes in bone marrow, spleen, liver and lymphnodes result in peripheral blood cytopenias, hepatosplenomegaly and lymphadenopathy. We evaluated a case of pyrexia of unknown origin and found out that he fulfilled the criteria for diagnosing hemophagocytic lymphohistiocytosis. He was started on immunochemotherapy with etoposide, cyclosporine and steroids, but he succumbed to illness within two weeks of treatment. High index of suspicion is needed to diagnose HLH and prompt treatment on diagnosis can be life savinghttps://mjhid.org/index.php/mjhid/article/view/1928Hemophagocytic lymphohistiocytosispyrexia of unknown originimmunochemotherapy |
| spellingShingle | Indira M Meera Nair Prabhalaksmi K K Andrews M A A case of Hemophagocytic Lymphohistiocytosis presenting as Pyrexia of Unknown Origin Mediterranean Journal of Hematology and Infectious Diseases Hemophagocytic lymphohistiocytosis pyrexia of unknown origin immunochemotherapy |
| title | A case of Hemophagocytic Lymphohistiocytosis presenting as Pyrexia of Unknown Origin |
| title_full | A case of Hemophagocytic Lymphohistiocytosis presenting as Pyrexia of Unknown Origin |
| title_fullStr | A case of Hemophagocytic Lymphohistiocytosis presenting as Pyrexia of Unknown Origin |
| title_full_unstemmed | A case of Hemophagocytic Lymphohistiocytosis presenting as Pyrexia of Unknown Origin |
| title_short | A case of Hemophagocytic Lymphohistiocytosis presenting as Pyrexia of Unknown Origin |
| title_sort | case of hemophagocytic lymphohistiocytosis presenting as pyrexia of unknown origin |
| topic | Hemophagocytic lymphohistiocytosis pyrexia of unknown origin immunochemotherapy |
| url | https://mjhid.org/index.php/mjhid/article/view/1928 |
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