Japanese encephalitis virus-associated human microglia induce cell death of human microvascular endothelial cells in receptor-independent infection

Japanese encephalitis virus-associated human microglia induce cell death of human microvascular endothelial cells in receptor-independent infection

IntroductionThe neurotropic virus Japanese encephalitis virus invades the human central nervous system, inducing neuroinflammation and further disruption of the blood-brain barrier. JEV interacts with various cell types of the blood-brain barrier including the endothelial cells. The present work aim...

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Bibliographic Details
Main Authors: Isabelle Fellay, Pauline Blanc, Alexey Larionov, Léa Schlunke, Luis Filgueira, Nils Lannes
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Japanese encephalitis (JE) virus
human microglia
microvascular endothelial cells
receptor-independent infection
intercellular interactions
cytotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1580958/full
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