An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer

An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer

Abstract The prostate‐specific membrane antigen (PSMA) has been demonstrated in numerous studies to be expressed specifically on prostate carcinoma cells and on the neovasculature of several other cancer entities. However, the simultaneous expression of PSMA on both, tumor cells as well as tumor ves...

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Main Authors: Latifa Zekri, Fabian Vogt, Lukas Osburg, Stefanie Müller, Joseph Kauer, Timo Manz, Martin Pflügler, Andreas Maurer, Jonas S Heitmann, Ilona Hagelstein, Melanie Märklin, Sebastian Hörner, Tilmann Todenhöfer, Carsten Calaminus, Arnulf Stenzl, Bernd Pichler, Christian la Fougère, Marc A Schneider, Hans‐Georg Rammensee, Lars Zender, Bence Sipos, Helmut R Salih, Gundram Jung
Format: Article
Language:English
Published: Springer Nature 2020-12-01
Series:EMBO Molecular Medicine
Subjects:
bispecific antibody
immunotherapy
lung cancer
prostate cancer
PSMA
Online Access:https://doi.org/10.15252/emmm.201911902
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