MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia
Sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is the major cause of frailty and falls in elders. The activation of inflammatory signal pathways due to diseases and aging is suggested to reveal the critical impact on...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/1438686 |
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| _version_ | 1832559931251752960 |
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| author | Jingjing Fan Xianjuan Kou Yi Yang Ning Chen |
| author_facet | Jingjing Fan Xianjuan Kou Yi Yang Ning Chen |
| author_sort | Jingjing Fan |
| collection | DOAJ |
| description | Sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is the major cause of frailty and falls in elders. The activation of inflammatory signal pathways due to diseases and aging is suggested to reveal the critical impact on sarcopenia. Several proinflammatory cytokines, especially interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), play crucial roles in modulation of inflammatory signaling pathway during the aging-related loss of skeletal muscle. MicroRNAs (miRNAs) have emerged as the important regulators for the mass and functional maintenance of skeletal muscle through regulating gene expression of proinflammatory cytokines. In this paper, we have systematically discussed regulatory mechanisms of miRNAs for the expression and secretion of inflammatory cytokines during sarcopenia, which will provide some novel targets and therapeutic strategies for controlling aging-related atrophy of skeletal muscle and corresponding chronic inflammatory diseases. |
| format | Article |
| id | doaj-art-c7f33b00e23e4a4880f375db6afa4f03 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c7f33b00e23e4a4880f375db6afa4f032025-02-03T01:28:57ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/14386861438686MicroRNA-Regulated Proinflammatory Cytokines in SarcopeniaJingjing Fan0Xianjuan Kou1Yi Yang2Ning Chen3Hubei Key Laboratory of Exercise Training and Monitoring, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science, Wuhan Sports University, Wuhan 430079, ChinaHubei Key Laboratory of Exercise Training and Monitoring, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science, Wuhan Sports University, Wuhan 430079, ChinaHubei Key Laboratory of Exercise Training and Monitoring, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science, Wuhan Sports University, Wuhan 430079, ChinaHubei Key Laboratory of Exercise Training and Monitoring, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science, Wuhan Sports University, Wuhan 430079, ChinaSarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is the major cause of frailty and falls in elders. The activation of inflammatory signal pathways due to diseases and aging is suggested to reveal the critical impact on sarcopenia. Several proinflammatory cytokines, especially interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), play crucial roles in modulation of inflammatory signaling pathway during the aging-related loss of skeletal muscle. MicroRNAs (miRNAs) have emerged as the important regulators for the mass and functional maintenance of skeletal muscle through regulating gene expression of proinflammatory cytokines. In this paper, we have systematically discussed regulatory mechanisms of miRNAs for the expression and secretion of inflammatory cytokines during sarcopenia, which will provide some novel targets and therapeutic strategies for controlling aging-related atrophy of skeletal muscle and corresponding chronic inflammatory diseases.http://dx.doi.org/10.1155/2016/1438686 |
| spellingShingle | Jingjing Fan Xianjuan Kou Yi Yang Ning Chen MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia Mediators of Inflammation |
| title | MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia |
| title_full | MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia |
| title_fullStr | MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia |
| title_full_unstemmed | MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia |
| title_short | MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia |
| title_sort | microrna regulated proinflammatory cytokines in sarcopenia |
| url | http://dx.doi.org/10.1155/2016/1438686 |
| work_keys_str_mv | AT jingjingfan micrornaregulatedproinflammatorycytokinesinsarcopenia AT xianjuankou micrornaregulatedproinflammatorycytokinesinsarcopenia AT yiyang micrornaregulatedproinflammatorycytokinesinsarcopenia AT ningchen micrornaregulatedproinflammatorycytokinesinsarcopenia |