Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: retrospective testing of specimens from the EURTAC trial.

Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: retrospective testing of specimens from the EURTAC trial.

The EURTAC trial demonstrated that the tyrosine kinase inhibitor (TKI) erlotinib was superior to chemotherapy as first-line therapy for advanced non-small cell lung cancers (NSCLC) that harbor EGFR activating mutations in a predominantly Caucasian population. Based on EURTAC and several Asian trials...

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Main Authors: Susana Benlloch, Maria Luisa Botero, Jordi Beltran-Alamillo, Clara Mayo, Ana Gimenez-Capitán, Itziar de Aguirre, Cristina Queralt, Jose Luis Ramirez, Santiago Ramón y Cajal, Barbara Klughammer, Mariette Schlegel, Walter Bordogna, David Chen, Guili Zhang, Barbara Kovach, Felice Shieh, John F Palma, Lin Wu, H Jeffrey Lawrence, Miquel Taron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089518&type=printable
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