Epistasis in the receptor-binding domain of contemporary H3N2 viruses that reverted to bind sialylated di-LacNAc repeats

Summary: Since their introduction into humans, H3N2 influenza A viruses have evolved continuously to escape immunity through antigenic drift, driven by mutations in and around the receptor-binding site. Recently, these changes resulted in viruses that recognize elongated glycans, which are less abun...

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Bibliographic Details
Main Authors: Ruonan Liang, Francesca Peccati, Niels L.D. Ponse, Elif Uslu, Annelies J.H. de Rooij, Alvin X. Han, Geert-Jan Boons, Luca Unione, Robert P. de Vries
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007788
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