USE OF HEPATOPROTECTORS IN PATIENTS WITH OVARIAN CANCER
Objective: to evaluate the efficiency of pharmacological correction of endogenous intoxication in patients with Stages III—IV ovarian cancer (OC) in the perioperative period. Subjects and methods. Thirty-to-70-year old seventy patients with Stages III-IV OC who had been surgically treated under gene...
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2015-05-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1456 |
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| author | S. V. Tumanyan N. D. Ushakova D. V. Yartseva |
| author_facet | S. V. Tumanyan N. D. Ushakova D. V. Yartseva |
| author_sort | S. V. Tumanyan |
| collection | DOAJ |
| description | Objective: to evaluate the efficiency of pharmacological correction of endogenous intoxication in patients with Stages III—IV ovarian cancer (OC) in the perioperative period. Subjects and methods. Thirty-to-70-year old seventy patients with Stages III-IV OC who had been surgically treated under general anesthesia were examined. The bio chemical parameters of intoxication, such as middleweight molecules, the total, effective concentration and binding capacity of albumin, integral hematological indices of intoxication, and C-reactive protein, were studied in the perioperative period. Results. Analysis of the performed tests showed that the premorbid background in all the examinees was characterized by varying degrees of endogenous intoxication (EI), increased leukocytic index of intoxication, hematological index of intoxication, and modified hematological index of intoxication, an imbalance between the accumulation and binding of overproduced toxic ligands, the intensified production of acutephase inflammatory proteins by the activation of a systemic inflammatory response, and decreased systemic responsiveness. These changes occur with suppressed systemic responsiveness, inadequate intoxication compensation by physiological detoxification systems and hemostatic instability. Conclusion. The use of heptral and Remaxol as part of the metabolic pharmacological correction infusion program nonequivalently caused reductions in the activity of an inflammatory response and the efficiency of EI correction in patients with OC in the perioperative period. The administration of Remaxol for systemic hyporesponsiveness and pronounced intoxication in OC patients promoted the optimization of systemic responsiveness, by producing a reduced toxic effect of tumorassociated EI. |
| format | Article |
| id | doaj-art-c7e5cfec6f434cbdbbfbd5a90beacf64 |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2015-05-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-c7e5cfec6f434cbdbbfbd5a90beacf642025-08-20T02:59:35ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102015-05-01112495510.15360/1813-9779-2015-2-49-551448USE OF HEPATOPROTECTORS IN PATIENTS WITH OVARIAN CANCERS. V. Tumanyan0N. D. Ushakova1D. V. Yartseva2Rostov Cancer Research Institute, Ministry of Health of Russia, Rostov-on-Don, Russia 63, 14th Line, Rostov-on-Don 344037, RussiaRostov Cancer Research Institute, Ministry of Health of Russia, Rostov-on-Don, Russia 63, 14th Line, Rostov-on-Don 344037, RussiaRostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia 29, Nakhichevansky Lane, Rostov-on-Don 344022Objective: to evaluate the efficiency of pharmacological correction of endogenous intoxication in patients with Stages III—IV ovarian cancer (OC) in the perioperative period. Subjects and methods. Thirty-to-70-year old seventy patients with Stages III-IV OC who had been surgically treated under general anesthesia were examined. The bio chemical parameters of intoxication, such as middleweight molecules, the total, effective concentration and binding capacity of albumin, integral hematological indices of intoxication, and C-reactive protein, were studied in the perioperative period. Results. Analysis of the performed tests showed that the premorbid background in all the examinees was characterized by varying degrees of endogenous intoxication (EI), increased leukocytic index of intoxication, hematological index of intoxication, and modified hematological index of intoxication, an imbalance between the accumulation and binding of overproduced toxic ligands, the intensified production of acutephase inflammatory proteins by the activation of a systemic inflammatory response, and decreased systemic responsiveness. These changes occur with suppressed systemic responsiveness, inadequate intoxication compensation by physiological detoxification systems and hemostatic instability. Conclusion. The use of heptral and Remaxol as part of the metabolic pharmacological correction infusion program nonequivalently caused reductions in the activity of an inflammatory response and the efficiency of EI correction in patients with OC in the perioperative period. The administration of Remaxol for systemic hyporesponsiveness and pronounced intoxication in OC patients promoted the optimization of systemic responsiveness, by producing a reduced toxic effect of tumorassociated EI.https://www.reanimatology.com/rmt/article/view/1456ovarian cancerendogenous intoxicationremaxolademethionine |
| spellingShingle | S. V. Tumanyan N. D. Ushakova D. V. Yartseva USE OF HEPATOPROTECTORS IN PATIENTS WITH OVARIAN CANCER Общая реаниматология ovarian cancer endogenous intoxication remaxol ademethionine |
| title | USE OF HEPATOPROTECTORS IN PATIENTS WITH OVARIAN CANCER |
| title_full | USE OF HEPATOPROTECTORS IN PATIENTS WITH OVARIAN CANCER |
| title_fullStr | USE OF HEPATOPROTECTORS IN PATIENTS WITH OVARIAN CANCER |
| title_full_unstemmed | USE OF HEPATOPROTECTORS IN PATIENTS WITH OVARIAN CANCER |
| title_short | USE OF HEPATOPROTECTORS IN PATIENTS WITH OVARIAN CANCER |
| title_sort | use of hepatoprotectors in patients with ovarian cancer |
| topic | ovarian cancer endogenous intoxication remaxol ademethionine |
| url | https://www.reanimatology.com/rmt/article/view/1456 |
| work_keys_str_mv | AT svtumanyan useofhepatoprotectorsinpatientswithovariancancer AT ndushakova useofhepatoprotectorsinpatientswithovariancancer AT dvyartseva useofhepatoprotectorsinpatientswithovariancancer |