Focal adhesion kinase promotes aerobic glycolysis in hepatic stellate cells via the cyclin D1/c-Myc/MCT-1 pathway to induce liver fibrosis

Focal adhesion kinase promotes aerobic glycolysis in hepatic stellate cells via the cyclin D1/c-Myc/MCT-1 pathway to induce liver fibrosis

Abstract Hepatic stellate cells (HSCs) transdifferentiate into myofibroblasts during liver fibrosis and exhibit increased glycolysis. Phosphorylated focal adhesion kinase (FAK) (pY397-FAK) promotes monocarboxylate transporter 1 (MCT-1) expression in HSCs to increase aerobic glycolysis and cause live...

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Bibliographic Details
Main Authors: Tao Huang, Ming-Yu Zhou, Gao-Liang Zou, Rui-Han Hu, Lu Han, Qing-Xiu Zhang, Xue-Ke Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Focal adhesion kinase
Liver fibrosis
Aerobic glycolysis
Monocarboxylate transporter 1
Multiomics analysis
Online Access:https://doi.org/10.1038/s41598-025-88538-8
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