Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study
Introduction: Thin invasive melanomas (Breslow thickness ≤1.0 mm) are increasing in incidence in Sweden, but also notably have a favorable prognosis. Treatment typically involves complete diagnostic excision followed by wide local excision (WLE) to eliminate potential microsatellite and satellite m...
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Mattioli1885
2025-04-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/5157 |
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| author | Ebba Wennberg Rudy Bittar Helena Svensson John Paoli |
| author_facet | Ebba Wennberg Rudy Bittar Helena Svensson John Paoli |
| author_sort | Ebba Wennberg |
| collection | DOAJ |
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Introduction: Thin invasive melanomas (Breslow thickness ≤1.0 mm) are increasing in incidence in Sweden, but also notably have a favorable prognosis. Treatment typically involves complete diagnostic excision followed by wide local excision (WLE) to eliminate potential microsatellite and satellite metastases, along with residual melanoma.
Objectives: This study aimed to investigate the frequency of microsatellite and satellite metastases in diagnostic excision specimens and residual melanoma in WLE specimens from thin melanomas.
Methods: This was a retrospective cohort study including consecutively collected primary thin melanomas excised at Sahlgrenska University Hospital between January 2014 and December 2020.
Results: Among 1,012 cases, no microsatellites were observed in the diagnostic excisions. Meanwhile, macroscopic satellite metastases were only present in 0.2% of the cases (n=2). Among 887 melanomas undergoing WLE with available data (87.6%), no microsatellites or satellite metastases were found in the extra tissue removed. Of the completely excised melanomas (n=936, 92.5%), only 0.2% (n=2) exhibited residual melanoma in the WLE.
Conclusions: Our findings align with previous studies suggesting that WLE may result in excessive and unnecessary treatment for completely excised thin melanomas. The requirement of performing WLEs following complete excision of thin melanomas needs to be reevaluated.
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| format | Article |
| id | doaj-art-c7e231c64eb443d7b394693262b4161c |
| institution | Kabale University |
| issn | 2160-9381 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Mattioli1885 |
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| series | Dermatology Practical & Conceptual |
| spelling | doaj-art-c7e231c64eb443d7b394693262b4161c2025-08-20T03:51:59ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-04-0115210.5826/dpc.1502a5157Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort StudyEbba Wennberg0https://orcid.org/0009-0005-9871-2675Rudy Bittar1Helena Svensson2https://orcid.org/0000-0001-6332-430XJohn Paoli3https://orcid.org/0000-0003-1326-8535Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden AND Department of Dermatology and Venereology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden AND Department of Dermatology and Venereology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden AND Department of Dermatology and Venereology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden Introduction: Thin invasive melanomas (Breslow thickness ≤1.0 mm) are increasing in incidence in Sweden, but also notably have a favorable prognosis. Treatment typically involves complete diagnostic excision followed by wide local excision (WLE) to eliminate potential microsatellite and satellite metastases, along with residual melanoma. Objectives: This study aimed to investigate the frequency of microsatellite and satellite metastases in diagnostic excision specimens and residual melanoma in WLE specimens from thin melanomas. Methods: This was a retrospective cohort study including consecutively collected primary thin melanomas excised at Sahlgrenska University Hospital between January 2014 and December 2020. Results: Among 1,012 cases, no microsatellites were observed in the diagnostic excisions. Meanwhile, macroscopic satellite metastases were only present in 0.2% of the cases (n=2). Among 887 melanomas undergoing WLE with available data (87.6%), no microsatellites or satellite metastases were found in the extra tissue removed. Of the completely excised melanomas (n=936, 92.5%), only 0.2% (n=2) exhibited residual melanoma in the WLE. Conclusions: Our findings align with previous studies suggesting that WLE may result in excessive and unnecessary treatment for completely excised thin melanomas. The requirement of performing WLEs following complete excision of thin melanomas needs to be reevaluated. https://dpcj.org/index.php/dpc/article/view/5157Microsatellite metastasessatellite metastasesresidual melanomathin melanomaWide local excisioninvasive melanoma |
| spellingShingle | Ebba Wennberg Rudy Bittar Helena Svensson John Paoli Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study Dermatology Practical & Conceptual Microsatellite metastases satellite metastases residual melanoma thin melanoma Wide local excision invasive melanoma |
| title | Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study |
| title_full | Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study |
| title_fullStr | Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study |
| title_full_unstemmed | Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study |
| title_short | Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study |
| title_sort | frequency of microsatellite metastases satellite metastases and residual tumor in thin melanomas a retrospective cohort study |
| topic | Microsatellite metastases satellite metastases residual melanoma thin melanoma Wide local excision invasive melanoma |
| url | https://dpcj.org/index.php/dpc/article/view/5157 |
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